MF: C24H32O4 MW: 384.51 A progesterone derivative with antineoplastic properties.
Protein-Interacting Inhibitors, Activators & Substrates
Androgen Receptor Inhibitors
Megestrol Acetate (CAS 595-33-5)
Megestrol Acetate is a progesterone derivative with antineoplastic properties
C 24H 32O 4
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For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. *
Certificate of Analysis for lot specific data (including water content).
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Megestrol Acetate is an inhibitor of Androgen Receptor (AR).
Sbrams JS, Gutheil J, Aisner J. Oncology. 49 Suppl 2:12-7 (1992). Sedlacek SM. Semin Oncol. 15:3-13 (1988).
Soluble in water (<1 mg/ml at 25° C), DMSO (33 mg/ml at 25° C), ethanol (15 mg/ml at 25° C), chloroform (1:0.8), and methanol.
20 D 1.55
α20/D +11°±2°, c = 2 in chloroform; α24/D +5° in chloroform
Progesterone receptor: IC
50 = 11 nM (bovine); GR: IC 50 = 19 nM (human); Androgen Receptor: IC 50 = 30 nM (rat); CYP2C9: IC 50 = 10 µM (human); HegG2: IC 50 = 260 µM
Progesterone receptor: K
i= 1.44 nM (bovine); GR: K i= 8.77 nM (human); Androgen Receptor: K i= 20 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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