Medroxyprogesterone 17-Acetate (CAS 71-58-9)

Appearance :

Crystalline powder

Physical State :

Solid

Solubility :

Soluble in DMF, ethanol (12 mg/ml at 25° C), methanol (sparingly), DMSO (12 mg/ml at 25° C), water (<1 mg/ml at 25° C), chloroform, and acetone.

Storage :

Store at -20° C

Melting Point :

206-207° C (lit.)

Boiling Point :

~496.4° C at 760 mmHg (Predicted)

Density :

~1.1 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.54 (Predicted)

Optical Activity :

α20_D +47, c = 1 in dioxane

IC50 :

Progesterone receptor: IC₅₀ = 2.25 nM (bovine); AR: IC₅₀ = 6.1 nM (human); GR: IC₅₀ = 10 nM (human); Estrogen receptor: IC₅₀ = 0.92 µM (human); MCR: IC₅₀ = 1.20 µM (human)

Ki Data :

Progesterone receptor: K_i= 0.29 nM (bovine); AR: K_i= 2.9 nM (human); GR: K_i= 8.6 nM (human); GABAA, Flunitrazepam, Central radioligand binding (ligand: [3H] Flunitrazepam): K_i= 6.31 µM; Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin): K_i= 13.41 µM

WGK Germany :

3

RTECS :

TU5010000

PubChem CID :

Merck Index :

14: 5793

MDL Number :

MFCD00010483

EC Number :

200-757-9

Beilstein Registry :

2066112

SMILES :

C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12