MEDICA 16 (CAS 87272-20-6)
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MEDICA 16, also known as 3,3,14,14-Tetramethylhexadecanedioic acid, is often studied for its inhibitory properties in biochemistry and enzymology. It is particularly of interest due to its ability to interfere with enzyme activities that involve long-chain fatty acids. The compound′s unique structure, featuring a long hydrocarbon chain with terminal carboxylic acid groups, allows it to mimic natural fatty acid substrates, which can lead to the inhibition of enzymes such as fatty acid synthase or fatty acid oxidation enzymes. This inhibition is valuable for understanding metabolic pathways involving fatty acids and for studying the regulation of lipid biosynthesis. Researchers also explore the impact of MEDICA 16 on metabolic disorders where modulation of lipid metabolism is relevant. Its role as an inhibitor provides insights into the development of new strategies for the control of metabolic pathways in various organisms.
MEDICA 16 (CAS 87272-20-6) References
- Peroxisome proliferators as adjuvants for the reverse-electron-transport therapy of obesity: an explanation for the large increase in metabolic rate of MEDICA 16-treated rats. | McCarty, MF. 1999. Med Hypotheses. 53: 272-6. PMID: 10608261
- MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats. | Atkinson, LL., et al. 2002. Diabetes. 51: 1548-55. PMID: 11978655
- Adipose tissue sensitization to insulin induced by troglitazone and MEDICA 16 in obese Zucker rats in vivo. | Kalderon, B., et al. 2003. Am J Physiol Endocrinol Metab. 284: E795-803. PMID: 12488241
- Effect of beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) on laying hen performance and egg yolk lipid composition. | Elkin, RG., et al. 1992. Br Poult Sci. 33: 677-81. PMID: 1643530
- Inhibition of rat liver acetyl-CoA carboxylase by beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16). | Rose-Kahn, G. and Bar-Tana, J. 1990. Biochim Biophys Acta. 1042: 259-64. PMID: 1967952
- Hypolipidemic effect of beta, beta'-tetramethyl hexadecanedioic acid (MEDICA 16) in hyperlipidemic JCR:LA-corpulent rats. | Russell, JC., et al. 1991. Arterioscler Thromb. 11: 602-9. PMID: 2029500
- Adipose reduction by beta,beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16). | Tzur, R., et al. 1989. Int J Obes. 13: 313-26. PMID: 2670791
- The induction of liver peroxisomal proliferation by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16). | Hertz, R., et al. 1988. Biochem Pharmacol. 37: 3571-7. PMID: 3178872
- The hypochylomicronemic effect of beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) is mediated by a decrease in apolipoprotein C-III. | Frenkel, B., et al. 1988. J Biol Chem. 263: 8491-7. PMID: 3372539
- Hypolipidemic effect of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats. | Bar-Tana, J., et al. 1988. J Lipid Res. 29: 431-41. PMID: 3392461
- The effect of beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: role of apolipoprotein C-III. | Frenkel, B., et al. 1994. Biochem J. 298 (Pt 2): 409-14. PMID: 8135749
- Hypocholesterolaemic effect of beta beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in the male hamster. | Mayorek, N. and Bar-Tana, J. 1993. Biochem J. 289 (Pt 3): 911-7. PMID: 8435085
- Sensitization to insulin induced by beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in obese Zucker rats in vivo. | Mayorek, N., et al. 1997. Diabetes. 46: 1958-64. PMID: 9392480
- Development of insulin resistance in the JCR:LA-cp rat: role of triacylglycerols and effects of MEDICA 16. | Russell, JC., et al. 1998. Diabetes. 47: 770-8. PMID: 9588449
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEDICA 16, 5 mg | sc-203131 | 5 mg | $188.00 | |||
MEDICA 16, 10 mg | sc-203131A | 10 mg | $260.00 |