Molecular structure of Medetomidine hydrochloride, CAS Number: 86347-15-1
Medetomidine hydrochloride (CAS 86347-15-1)
See product citations (2)
Alternate Names:
Medetomidine hydrochloride is also known as MPV 785.
Application:
Medetomidine hydrochloride is a potent and highly selective α2-adrenoceptor agonist used as an anesthetic and analgesic.
CAS Number:
86347-15-1
Purity:
≥99%
Molecular Weight:
236.74
Molecular Formula:
C13H16N2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Medetomidine hydrochloride is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Medetomidine hydrochloride shows greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine hydrochloride influences the adrenergic system by mimicking the action of adrenergic neurotransmitters. Medetomidine hydrochloride is an imidazole compound.
Medetomidine hydrochloride (CAS 86347-15-1) References
- Cardiopulmonary and sedative effects of intravenous administration of low doses of medetomidine and xylazine to adult horses. | Bueno, AC., et al. 1999. Am J Vet Res. 60: 1371-6. PMID: 10566811
- Determination of optimal immobilizing doses of a medetomidine hydrochloride and ketamine hydrochloride combination in captive reindeer. | Ryeng, KA., et al. 2001. Am J Vet Res. 62: 119-26. PMID: 11197548
- Cardiopulmonary evaluation of the use of medetomidine hydrochloride in cats. | Lamont, LA., et al. 2001. Am J Vet Res. 62: 1745-9. PMID: 11703018
- Experimental comparison of ketamine with a combination of ketamine, butorphanol and medetomidine for general anaesthesia of the Eurasian badger (Meles meles L.). | de Leeuw, AN., et al. 2004. Vet J. 167: 186-93. PMID: 14975394
- Immobilisation of impala (Aepyceros melampus) with a ketamine hydrochloride/medetomidine hydrochloride combination, and reversal with atipamezole hydrochloride. | Bush, M., et al. 2004. J S Afr Vet Assoc. 75: 14-8. PMID: 15214689
- Sedative and cardiopulmonary effects of medetomidine hydrochloride and xylazine hydrochloride and their reversal with atipamezole hydrochloride in calves. | Rioja, E., et al. 2008. Am J Vet Res. 69: 319-29. PMID: 18312129
- Comparison of the diuretic effects of medetomidine hydrochloride and xylazine hydrochloride in healthy cats. | Murahata, Y. and Hikasa, Y. 2012. Am J Vet Res. 73: 1871-80. PMID: 23176412
- Medetomidine--a novel alpha 2-adrenoceptor agonist: a review of its pharmacodynamic effects. | Scheinin, H., et al. 1989. Prog Neuropsychopharmacol Biol Psychiatry. 13: 635-51. PMID: 2571177
- Uterine motor responses to an alpha 2-adrenergic agonist medetomidine hydrochloride in the bitches during the end of gestation and the post-partum period. | Jedruch, J., et al. 1989. Acta Vet Scand Suppl. 85: 129-34. PMID: 2571262
- Effects of a medetomidine-ketamine combination on Schirmer tear test I results of clinically normal cats. | Di Pietro, S., et al. 2016. Am J Vet Res. 77: 310-4. PMID: 26919603
- Puppy survival and vigor associated with the use of low dose medetomidine premedication, propofol induction and maintenance of anesthesia using sevoflurane gas-inhalation for cesarean section in the bitch. | De Cramer, KGM., et al. 2017. Theriogenology. 96: 10-15. PMID: 28532824
- Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoreceptors. | Savola, JM., et al. 1986. J Auton Pharmacol. 6: 275-84. PMID: 2880852
- Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. | Virtanen, R., et al. 1988. Eur J Pharmacol. 150: 9-14. PMID: 2900154
- Cardiovascular and sedation reversal effects of intramuscular administration of atipamezole in dogs treated with medetomidine hydrochloride with or without the peripheral α2-adrenoceptor antagonist vatinoxan hydrochloride. | Turunen, H., et al. 2019. Am J Vet Res. 80: 912-922. PMID: 31556714
- An evaluation of the influence of medetomidine hydrochloride and atipamezole hydrochloride on the arrhythmogenic dose of epinephrine in dogs during halothane anesthesia. | Pettifer, GR., et al. 1996. Can J Vet Res. 60: 1-6. PMID: 8825986
Activator of:
alpha2A-AR, alpha2B-AR, and alpha2C-AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Medetomidine hydrochloride, 10 mg | sc-204073 | 10 mg | $123.00 | |||
Medetomidine hydrochloride, 50 mg | sc-204073A | 50 mg | $495.00 |