Medetomidine hydrochloride CAS: 86347-15-1
MF: C13H16N2•HCl
MW: 236.74

Medetomidine hydrochloride (CAS 86347-15-1)

Medetomidine hydrochloride | CAS 86347-15-1 is rated 5.0 out of 5 by 1.
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Alternate Names: Medetomidine hydrochloride is also known as MPV 785.
Application: Medetomidine hydrochloride is a potent and highly selective α2-adrenoceptor agonist used as an anesthetic and analgesic.
CAS Number: 86347-15-1
Purity: ≥99%
Molecular Weight: 236.74
Molecular Formula: C13H16N2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Medetomidine hydrochloride is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Medetomidine hydrochloride shows greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Medetomidine hydrochloride is used in clinical and surgical procedures as an anesthetic and analgesic. Medetomidine hydrochloride is an imidazole derivative.


References

1. Savola et al (1986) Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoceptors. J.Aut.Pharmacol. 6 275.
2. Virtanen et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an a2-adrenoceptor agonist. Eur.J.Pharmacol. 150 9.
3. Scheinin et al (1989) Medetomidine - a novel a2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and methanol.
Storage :
Desiccate at room temperature
Melting Point :
176-179° C
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
α2A-AR: IC50 = 3.3 µM (human)
Ki Data :
α2D receptors: Ki= 0.76 nM; α2-adrenoceptor agonist : Ki= 1.08 nM; α2C receptors: Ki= 12.3 nM; α1-adrenoceptors: Ki= 1.75 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
68601
MDL Number :
MFCD06798319
Beilstein Registry :
4890476
SMILES :
CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C.Cl

Download SDS (MSDS)

Certificate of Analysis

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Medetomidine hydrochloride (CAS 86347-15-1)  Product Citations

See how others have used Medetomidine hydrochloride (CAS 86347-15-1). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 27147677  Wang, X. et al. 2016. Biomed Mater. 11: 035005.

PMID: # 26273963  You, Y. et al. 2015. J Vis Exp. e52934.

Citations 1 to 2 of 2 total

I see that the melt temp is 176-179C. Do you know the thermal decomposition temperature max with-stand temperature?

Asked by: PDWs
Thank you for your question. The thermal decomposition temperature maximum of Medetomidine hydrochloride (CAS 86347-15-1) is not information that we have available at this time.
Answered by: Technical Support
Date published: 2017-05-09

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The appearance of this compound is a white or off-white crystalline powder.
Answered by: Technical Support
Date published: 2017-01-18

What is the appearance of the chemical?

Asked by: two2igm05
Thank you for your question. The compound, sc-204073, is provided as a white to off-white crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-12

The potency is listed as 99.22%. Is this “as is” or was it calculated with the LOD factor of 0.67% and therefore “dry basis”?

Asked by: two2igm05
Assay (calculated as dry basis) means the total impurities don't include water. For example, assay 99.22%, means the 0.78% impurities don't include water. Loss on drying includes water and solvents residue.
Answered by: Tech Service 4
Date published: 2016-12-16
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Rated 5 out of 5 by from Medetomidine hydrochloride was reported as an 2 Medetomidine hydrochloride was reported as an 2 -adrenergic receptor-agonist used as an anesthetic in animals. -SCBT Publication Review
Date published: 2015-07-14
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