Molecular structure of Meclofenamate sodium, CAS Number: 6385-02-0
Meclofenamate sodium (CAS 6385-02-0)
See product citations (2)
Alternate Names:
Meclofenamic acid sodium salt; 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt
Application:
Meclofenamate sodium is an inhibitor of 5-LO, Cox-1, and Cox-2
CAS Number:
6385-02-0
Purity:
≥98%
Molecular Weight:
318.13
Molecular Formula:
C14H10Cl2NO2•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Meclofenamate sodium is a dual inhibitor of the 5-LO (5-lipoxygenase) and Cox (cyclooxygenase) pathways. Meclofenamate sodium is demonstrated to inhibit both Cox-1 and Cox-2, showing micromolar inhibition of human recombinant hCox-1 (IC50 of 1.5 muM) and hCox-2 (IC50 of 9.7 muM). An irreversible time-dependent inhibition of hCOX-2 is described, involving a rapid equilibrium binding of enzyme and inhibitor followed by formation of a tightly bound inhibited complex.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Meclofenamate sodium (CAS 6385-02-0) References
- The protective effect of sodium meclofenamate in experimental endotoxin shock. | Parratt, JR. and Sturgess, RM. 1975. Br J Pharmacol. 53: 466P. PMID: 1093598
- QSAR analysis of meclofenamic acid analogues as selective COX-2 inhibitors. | Narsinghani, T. and Chaturvedi, SC. 2006. Bioorg Med Chem Lett. 16: 461-8. PMID: 16290292
- A single and multiple dose pharmacokinetic and metabolism study of meclofenamate sodium. | Koup, JR., et al. 1990. Biopharm Drug Dispos. 11: 1-15. PMID: 2322633
- Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. | Huang, Y., et al. 2015. Nucleic Acids Res. 43: 373-84. PMID: 25452335
- Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. | Ghosh, R., et al. 2016. J Mol Cell Cardiol. 94: 131-144. PMID: 27049794
- Meclofenamate sodium is an inhibitor of both the 5-lipoxygenase and cyclooxygenase pathways of the arachidonic acid cascade in vitro. | Boctor, AM., et al. 1986. Prostaglandins Leukot Med. 23: 229-38. PMID: 3020588
- Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. | Rampart, M. and Williams, TJ. 1986. Biochem Pharmacol. 35: 581-6. PMID: 3081008
- Comparison of meclofenamate sodium and hydrocortisone for controlling the postsurgical inflammatory response in rats. | Shieh, HL., et al. 1988. J Oral Maxillofac Surg. 46: 777-80. PMID: 3166048
- Intraluteal infusion of a prostaglandin synthesis inhibitor, sodium meclofenamate, causes premature luteolysis in rhesus monkeys. | Sargent, EL., et al. 1988. Endocrinology. 123: 2261-9. PMID: 3168922
- Copper(II) complexes with meclofenamate ligands: Structure, interaction with DNA and albumins, antioxidant and anticholinergic activity. | Barmpa, A., et al. 2021. J Inorg Biochem. 217: 111357. PMID: 33556771
- Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma. | Schneider, M., et al. 2021. Neuro Oncol. 23: 1885-1897. PMID: 33864086
- Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. | Ouellet, M. and Percival, MD. 1995. Biochem J. 306 (Pt 1): 247-51. PMID: 7864817
- Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. | Laneuville, O., et al. 1994. J Pharmacol Exp Ther. 271: 927-34. PMID: 7965814
Inhibitor of:
5-LO, Cox-2, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Meclofenamate sodium, 1 g | sc-200532 | 1 g | $51.00 | |||
Meclofenamate sodium, 5 g | sc-200532A | 5 g | $77.00 |