Meclizine-d8 Dihydrochloride (CAS 1104-22-9 (unlabeled))
QUICK LINKS
Meclizine-d8 Dihydrochloride is a labeled form of Meclizine Dihydrochloride (sc-211779), which functions as an antagonist at H1 receptors. It is known that Meclizine-d8 Dihydrochloride is similar in structure to Buclizine Dihydrochloride (sc-210969), cyclizine, and Hydroxyzine Dihydrochloride (sc-205716), but has a shorter half-life. In addition, Meclizine-d8 Dihydrochloride acts as an anticholinergic agent. Alternate studies suggest that Meclizine-d8 Dihydrochloride binds to the human pregnane X receptor (hPXR), which in turn recruits coactivator-1 to the receptor. Also Meclizine-d8 Dihydrochloride increases CYP3A4 gene expression, while decreasing the activity of testosterone 6β-hydroxylation which is catalyzed by the enzyme CYP3A.
Meclizine-d8 Dihydrochloride (CAS 1104-22-9 (unlabeled)) References
- Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine. | Lin, JC., et al. 2007. Food Chem Toxicol. 45: 935-44. PMID: 17222494
- Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. | Lau, AJ., et al. 2011. J Pharmacol Exp Ther. 336: 816-26. PMID: 21131266
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Meclizine-d8 Dihydrochloride, 1 mg | sc-218677 | 1 mg | $290.00 |