Molecular structure of Mecamylamine Hydrochloride, CAS Number: 826-39-1
Mecamylamine Hydrochloride (CAS 826-39-1)
See product citations (3)
Alternate Names:
2-(Methylamino)isocamphane hydrochloride
Application:
Mecamylamine Hydrochloride is a noncompetitive nicotinic AChR inhibitor
CAS Number:
826-39-1
Molecular Weight:
203.75
Molecular Formula:
C11H21N•HCl
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mecamylamine Hydrochloride is a noncompetitive and nonselective antagonist of AChRs. The compound preferentially blocks nicotinic receptors at autonomic ganglia and is able to cross the blood brain barrier. Once across the blood brain barrier Mecamylamine Hydrochloride can selectively antagonize neuronal AChRs. Mecamylamine Hydrochloride is an inhibitor of AChR alpha 3, AChR alpha 4, AChR alpha 7 and AChRbeta2.
Mecamylamine Hydrochloride (CAS 826-39-1) References
- Mecamylamine: new therapeutic uses and toxicity/risk profile. | Young, JM., et al. 2001. Clin Ther. 23: 532-65. PMID: 11354389
- Effects of nicotine, mecamylamine, and hexamethonium on shock-induced fighting, pain reactivity, and locomotor behaviour in rats. | Rodgers, RJ. 1979. Psychopharmacology (Berl). 66: 93-8. PMID: 120548
- MECAMYLAMINE hydrochloride. | . 1956. J Am Med Assoc. 162: 1469-71. PMID: 13376320
- Mecamylamine hydrochloride in the treatment of hypertension. | DATEY, KK. and JOSHI, NK. 1958. J Indian Med Assoc. 30: 43-50. PMID: 13514093
- Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. | Bacher, I., et al. 2009. Expert Opin Pharmacother. 10: 2709-21. PMID: 19874251
- Distinct roles of cholinergic receptors in small cell lung cancer cells. | Zhang, S., et al. 2010. Anticancer Res. 30: 97-106. PMID: 20150622
- Nicotine-induced impulsive action: sensitization and attenuation by mecamylamine. | Kirshenbaum, AP., et al. 2011. Behav Pharmacol. 22: 207-21. PMID: 21448062
- Nicotine Directly Induces Endoplasmic Reticulum Stress Response in Rat Placental Trophoblast Giant Cells. | Wong, MK., et al. 2016. Toxicol Sci. 151: 23-34. PMID: 26803847
- Pharmacologic characterization of nicotine-induced conditioned place preference. | Fudala, PJ., et al. 1985. Pharmacol Biochem Behav. 22: 237-41. PMID: 2858867
- Protective effect of electro-acupuncture on liver ischemia-reperfusion injury in rats. | Li, Y., et al. 2018. Exp Ther Med. 16: 1373-1380. PMID: 30116387
- Matured hop bitter acids improve spatial working and object recognition memory via nicotinic acetylcholine receptors. | Fukuda, T., et al. 2019. Psychopharmacology (Berl). 236: 2847-2854. PMID: 31069423
- Varenicline Prevents LPS-Induced Inflammatory Response via Nicotinic Acetylcholine Receptors in RAW 264.7 Macrophages. | Baris, E., et al. 2021. Front Mol Biosci. 8: 721533. PMID: 34712695
- Nicotine-induced taste aversion: characterization and preexposure effects in rats. | Iwamoto, ET. and Williamson, EC. 1984. Pharmacol Biochem Behav. 21: 527-32. PMID: 6504950
Inhibitor of:
AChR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mecamylamine Hydrochloride, 5 mg | sc-205742 | 5 mg | $82.00 | |||
Mecamylamine Hydrochloride, 25 mg | sc-205742A | 25 mg | $260.00 |