Mecamylamine Hydrochloride CAS: 826-39-1
MF: C11H21N•HCl
MW: 203.75
A noncompetitive nicotinic AChR inhibitor.

Mecamylamine Hydrochloride (CAS 826-39-1)

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Alternate Names: 2-(Methylamino)isocamphane hydrochloride
Application: Mecamylamine Hydrochloride is a noncompetitive nicotinic AChR inhibitor
CAS Number: 826-39-1
Molecular Weight: 203.75
Molecular Formula: C11H21N•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Mecamylamine Hydrochloride is a noncompetitive and nonselective antagonist of AChRs. The compound preferentially blocks nicotinic receptors at autonomic ganglia and is able to cross the blood brain barrier. Once across the blood brain barrier Mecamylamine Hydrochloride can selectively antagonize neuronal AChRs. Mecamylamine Hydrochloride is an inhibitor of AChR α 3, AChR α 4, AChR α 7 and AChRβ2.


References

1. Rodgers, R.J. 1979. Psychopharmacology. 66: 93-98. PMID: 120548
2. Young, J.M., et al. 2001. Clin Ther. 23: 532-565. PMID: 11354389
3. Bacher, I., et al. 2009. Expert Opin Pharmacother. 10: 2709-2721. PMID: 19874251

Physical State :
Solid
Storage :
Store at room temperature
Melting Point :
245.5-246.5° C (dec.)
Boiling Point :
189.3° C at 760 mmHg (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
RB6900000
PubChem CID :
13221
MDL Number :
MFCD00151462
EC Number :
212-555-8
SMILES :
CC1(C2CCC(C2)C1(C)NC)C.Cl

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Certificate of Analysis

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Mecamylamine Hydrochloride (CAS 826-39-1)  Product Citations

See how others have used Mecamylamine Hydrochloride (CAS 826-39-1). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26803847  Wong, MK. et al. 2016. Toxicological sciences : an official journal of the Society of Toxicology. 151: 23-34.

PMID: # 31580752  J Med Food. 388-394.

Citations 1 to 2 of 2 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Mecamylamine Hydrochloride, sc-205742, is lyophilized powder.
Answered by: Chemical Support 4
Date published: 2017-04-06
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