Date published: 2025-10-15

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MeBIO (CAS 667463-95-8)

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Alternate Names:
1-Methyl-BIO; (2′Z,3′E)-6-Bromo-1-methylindirubin-3′-oxime
Application:
MeBIO is a control analog of BIO which displays minimal activity against CDK1/Cyclin B & GSK-3 α/β
CAS Number:
667463-95-8
Purity:
≥99%
Molecular Weight:
370.20
Molecular Formula:
C17H12BrN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

MeBIO is an inactive control analog of the GSK-3 Inhibitor IX (BIO, sc-202634). MeBIO exhibits minimal activity against CDK1/Cyclin B, GSK-3 α/β and CDK5/p25. An aryl hydrocarbon receptor (AhR) activator.


MeBIO (CAS 667463-95-8) References

  1. [A clinical study of cryptococcal meningitis--sequential changes of cryptococcal antigen titers].  |  Kishi, K., et al. 2003. Kansenshogaku Zasshi. 77: 150-7. PMID: 12708008
  2. GSK-3-selective inhibitors derived from Tyrian purple indirubins.  |  Meijer, L., et al. 2003. Chem Biol. 10: 1255-66. PMID: 14700633
  3. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.  |  Polychronopoulos, P., et al. 2004. J Med Chem. 47: 935-46. PMID: 14761195
  4. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes.  |  Tseng, AS., et al. 2006. Chem Biol. 13: 957-63. PMID: 16984885
  5. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.  |  Trivedi, CM., et al. 2007. Nat Med. 13: 324-31. PMID: 17322895
  6. Ca(2+) regulates the subcellular localization of adenomatous polyposis coli tumor suppressor protein.  |  Togo, T. 2009. Biochem Biophys Res Commun. 388: 12-6. PMID: 19638276
  7. Dynamic telomerase gene suppression via network effects of GSK3 inhibition.  |  Bilsland, AE., et al. 2009. PLoS One. 4: e6459. PMID: 19649288
  8. cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase.  |  Johnston, A., et al. 2011. Am J Physiol Gastrointest Liver Physiol. 301: G385-400. PMID: 21546580
  9. Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments.  |  Williams, SP., et al. 2011. Cancer Res. 71: 5374-80. PMID: 21697283
  10. Smooth muscle phenotypic diversity is mediated through alterations in myocardin gene splicing.  |  Ilagan, RM., et al. 2011. J Cell Physiol. 226: 2702-11. PMID: 21792927
  11. Human chondrogenic paraxial mesoderm, directed specification and prospective isolation from pluripotent stem cells.  |  Umeda, K., et al. 2012. Sci Rep. 2: 455. PMID: 22701159
  12. EpCAM Induction Functionally Links to the Wnt-Enhanced Cell Proliferation in Human Keratinocytes.  |  Shen, CI., et al. 2014. Cell Transplant. 23: 1031-1044. PMID: 23635478
  13. Anteroposterior Patterning of Gene Expression in the Human Infant Sclera: Chondrogenic Potential and Wnt Signaling.  |  Seko, Y., et al. 2017. Curr Eye Res. 42: 145-154. PMID: 27336854

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

MeBIO, 10 mg

sc-357370
10 mg
$160.00
US: Only available in the US