MDR3/ABCB4 Antibody (P3-II-26): sc-551480

Mdr-3 Antibody (P3-II-26) is a mouse monoclonal IgG2b antibody raised against amino acids 629-692 of Mdr-3 of human origin and is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Mdr-3 monoclonal antibody (P3-II-26) is available as a non-conjugated anti-Mdr-3 antibody, providing researchers with a reliable tool for studying this important protein. Mdr-3, also known as ABCB4, plays a crucial role in the transport of phospholipids and other molecules across cellular membranes, which is vital for maintaining cellular homeostasis and lipid metabolism. ABCB4 function is particularly significant in the liver, where ABCB4 contributes to the secretion of bile acids and phospholipids, thereby influencing digestion and absorption of dietary fats. ABCB4 is localized to the canalicular membrane of hepatocytes, where ABCB4 facilitates the export of phosphatidylcholine into bile, protecting bile ducts from the detergent effects of bile acids. This localization underscores the essential role of ABCB4 in bile composition and the prevention of cholestatic liver diseases. Dysregulation of ABCB4 can lead to various liver diseases and has been implicated in the development of drug resistance in cancer, making ABCB4 a key target for therapeutic intervention. Anti-Mdr-3 antibody (P3-II-26) enables researchers to gain insights into the mechanisms of multidrug resistance and the physiological roles of this essential protein.

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MDR3/ABCB4 Antibody (P3-II-26) References:

1. Preliminary immunocytochemical studies of MDR-1 and MDR-3 Pgp expression in B-cell leukaemias.  |  Larkin, A., et al. 1999. Adv Exp Med Biol. 457: 65-70. PMID: 10500781
2. Insertion of a retroviral solo long terminal repeat in mdr-3 locus disrupts mRNA splicing in mice.  |  Jun, K., et al. 2000. Mamm Genome. 11: 843-8. PMID: 11003697
3. Down-regulation of ras and myc expression associated with mdr-1 overexpression in adriamycin-resistant tumor cells.  |  Banerjee, S., et al. 1992. Cell Mol Biol. 38: 561-70. PMID: 1363885
4. Murine mdr-1, mdr-2, and mdr-3 gene expression: no coinduction with the Cyp1a-1 and Nmo-1 genes in liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin.  |  Teeter, LD., et al. 1991. DNA Cell Biol. 10: 433-41. PMID: 2069718
5. Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen.  |  Alvarez, M., et al. 1995. J Clin Invest. 95: 2205-14. PMID: 7738186
6. MDR-related P170-glycoprotein modulates cytotoxic activity of homoharringtonine.  |  Russo, D., et al. 1995. Leukemia. 9: 513-6. PMID: 7885049
7. P-glycoprotein (MDR 1 gene product) in cells of the immune system: its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection.  |  Gupta, S. and Gollapudi, S. 1993. J Clin Immunol. 13: 289-301. PMID: 7902361
8. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.  |  Zaman, GJ., et al. 1994. Proc Natl Acad Sci U S A. 91: 8822-6. PMID: 7916458
9. Functional studies of P-glycoprotein in inside-out plasma membrane vesicles derived from murine erythroleukemia cells overexpressing MDR 3. Properties and kinetics of the interaction of vinblastine with P-glycoprotein and evidence for its active mediated transport.  |  Schlemmer, SR. and Sirotnak, FM. 1994. J Biol Chem. 269: 31059-66. PMID: 7983045
10. Levels of expression of mdr-3 and glutathione-S-transferase genes in chronic lymphocytic leukemia lymphocytes.  |  Warr, JR., et al. 1993. Blood. 82: 1937-8. PMID: 8400244
11. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines.  |  Zaman, GJ., et al. 1993. Cancer Res. 53: 1747-50. PMID: 8467491
12. A new monoclonal antibody that specifically recognises the MDR-3-encoded gene product.  |  Larkin, A., et al. 1999. Int J Cancer. 80: 265-71. PMID: 9935209

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MDR3/ABCB4 Antibody (P3-II-26) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MDR3/ABCB4 Antibody (P3-II-26) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MDR3/ABCB4 Antibody (P3-II-26) Specifications

Alternate Product Name: Mdr-3

Product Clone Name: P3-II-26

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids: 629-692

Epitope Target: Mdr-3

Epitope Species: human

Product Reactivity/Detection: Mdr-3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 50 µg IgG_2b in 0.5 ml of PBS with 0.1% BSA and 0.02% sodium azide

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MDR3/ABCB4 Antibody (P3-II-26): N/A