Molecular structure of MDM2 Inhibitor, CAS Number: 562823-84-1
MDM2 Inhibitor Inhibitor (CAS 562823-84-1)
Alternate Names:
trans-4-Iodo-4′-boranyl-chalcone; MDM2 Antagonist IV
Application:
MDM2 Inhibitor is a cell-permeable boranyl-chalcone that binds to MDM2 and disrupts MDM2/p53 protein complex
CAS Number:
562823-84-1
Purity:
≥95%
Molecular Weight:
377.97
Molecular Formula:
C15H12BIO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
MDM2 Inhibitor is a cell-permeable boranyl-chalcone exhibiting strong binding to MDM2 and irreversibly disrupts the MDM2/p53 protein complex. MDM2 Inhibitor expresses selective toxicity towards MDM2 overexpressing human breast cancer cell lines when compared to normal breast cell lines.
MDM2 Inhibitor Inhibitor (CAS 562823-84-1) References
- Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors. | Aizu, W., et al. 2006. Biochem Pharmacol. 72: 981-91. PMID: 16949053
- Stabilization of p53 in human cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination. | Chen, Z., et al. 2007. J Biol Chem. 282: 29284-95. PMID: 17698841
- Anoikis triggers Mdm2-dependent p53 degradation. | Ghosh, A., et al. 2010. Mol Cell Biochem. 343: 201-9. PMID: 20577896
- NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2. | Busuttil, V., et al. 2010. Proc Natl Acad Sci U S A. 107: 18061-6. PMID: 20921405
- An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts. | Matsushima, S., et al. 2011. Biochem Biophys Res Commun. 407: 557-61. PMID: 21419099
- FOXL2 posttranslational modifications mediated by GSK3β determine the growth of granulosa cell tumours. | Kim, JH., et al. 2014. Nat Commun. 5: 2936. PMID: 24390485
- Molecular targeted approaches to cancer therapy and prevention using chalcones. | Jandial, DD., et al. 2014. Curr Cancer Drug Targets. 14: 181-200. PMID: 24467530
- Boron's neurophysiological effects and tumoricidal activity on glioblastoma cells with implications for clinical treatment. | Altinoz, MA., et al. 2019. Int J Neurosci. 129: 963-977. PMID: 30885023
- A comprehensive review on the antiviral activities of chalcones. | Elkhalifa, D., et al. 2021. J Drug Target. 29: 403-419. PMID: 33232192
Inhibitor of:
Apg-1, and MDM2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDM2 Inhibitor, 10 mg | sc-204072 | 10 mg | $172.00 |