Molecular structure of MDL 72832 hydrochloride, CAS Number: 113777-33-6
MDL 72832 hydrochloride (CAS 113777-33-6)
Alternate Names:
8-[4-(1,4-Benzodioxan-2-ylmethylamino)butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride
Application:
MDL 72832 hydrochloride is a post-synapticSR-1A (5-HT1A receptors) agonist
CAS Number:
113777-33-6
Molecular Weight:
422.95
Molecular Formula:
C22H30N2O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
MDL 72832 hydrochloride is a potent, selective and stereospecific ligand for 5-HT1A receptors which possesses both agonist and antagonist properties. At post-synaptic SR-1A (5-HT1A receptors), it acts as a specific agonist.
MDL 72832 hydrochloride (CAS 113777-33-6) References
- Alpha-adrenoceptors in canine mesenteric artery are predominantly 1A subtype: pharmacological and immunochemical evidence. | Daniel, EE., et al. 1999. J Pharmacol Exp Ther. 291: 671-9. PMID: 10525087
- Performance of a passive avoidance response is disrupted by compounds acting at 5HT(1A) receptors. | Sanger, DJ. and Joly, D. 1989. Behav Pharmacol. 1: 235-240. PMID: 11224034
- Discriminative stimulus properties of 8-OH-DPAT: relationship to affinity for 5HT1A receptors. | Sanger, DJ. and Schoemaker, H. 1992. Psychopharmacology (Berl). 108: 85-92. PMID: 1357711
- 5-HT1-like receptor agonists enhance wakefulness. | Dzoljic, MR., et al. 1992. Neuropharmacology. 31: 623-33. PMID: 1407402
- Contractile 5-HT1 receptors in human isolated pial arterioles: correlation with 5-HT1D binding sites. | Hamel, E. and Bouchard, D. 1991. Br J Pharmacol. 102: 227-33. PMID: 2043924
- 1,9-Alkano-bridged 2,3,4,5-tetrahydro-1H-3-benzazepines with affinity for the alpha 2-adrenoceptor and the 5-HT1A receptor. | Clark, RD., et al. 1990. J Med Chem. 33: 633-41. PMID: 2153822
- The concept of selectivity in 5-HT receptor research. | van Wijngaarden, I., et al. 1990. Eur J Pharmacol. 188: 301-12. PMID: 2164935
- MDL 73005EF: partial agonist at the 5-HT1A receptor negatively linked to adenylate cyclase. | Cornfield, LJ., et al. 1989. Eur J Pharmacol. 173: 189-92. PMID: 2560432
- MDL 72832: a potent and stereoselective ligand at central and peripheral 5-HT1A receptors. | Mir, AK., et al. 1988. Eur J Pharmacol. 149: 107-20. PMID: 2840295
- MDL 72832, a selective 5-HT1A receptor ligand, stereospecifically increases food intake. | Neill, JC. and Cooper, SJ. 1988. Eur J Pharmacol. 151: 329-32. PMID: 3169126
- Current Therapeutic Approaches to Anorexia Nervosa: State of the Art. | Muratore, AF. and Attia, E. 2021. Clin Ther. 43: 85-94. PMID: 33293054
- Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor. | Hibert, MF., et al. 1988. J Med Chem. 31: 1087-93. PMID: 3373482
- 5-HT1A receptor influences on rodent social and agonistic behavior: a review and empirical study. | Bell, R. and Hobson, H. 1994. Neurosci Biobehav Rev. 18: 325-38. PMID: 7984351
- Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. | Millan, MJ., et al. 1993. J Pharmacol Exp Ther. 264: 1364-76. PMID: 8450471
- Pharmacological and immunocytochemical characterization of subtypes of alpha-1 adrenoceptors in dog aorta. | Low, AM., et al. 1998. J Pharmacol Exp Ther. 285: 894-901. PMID: 9580641
Activator of:
SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDL 72832 hydrochloride, 10 mg | sc-204070 | 10 mg | $150.00 | |||
MDL 72832 hydrochloride, 50 mg | sc-204070A | 50 mg | $605.00 |