Molecular structure of MDL 72527, CAS Number: 93565-01-6
MDL 72527 (CAS 93565-01-6)
Alternate Names:
N1,N4-Di-2,3-butadienyl-1,4-butanediamine dihydrochloride; n,n′-Di(buta-2,3-dien-1-yl)butane-1,4-diamine
CAS Number:
93565-01-6
Purity:
≥95%
Molecular Weight:
265.23
Molecular Formula:
C12H22Cl2N2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
MDL 72527 is a naturally occurring compound that acts as an inhibitor of polyamine oxidase (PAO), an enzyme responsible for the oxidation of polyamines. Does not inhibit monoamine oxidase or D-Amino acid oxidase. In addition, this compound triggers apoptosis by disrupting the mitochondrial membrane potential. Studies have demonstrated its superior potency compared to protocatechuic acid, and extended exposure to cells can result in irreversible inhibition.
MDL 72527 (CAS 93565-01-6) References
- Effect of the polyamine oxidase inactivator MDL 72527 on N(1)-(n-octanesulfonyl)spermine toxicity. | Seiler, N., et al. 2000. Int J Biochem Cell Biol. 32: 1055-68. PMID: 11091138
- The polyamine oxidase inactivator MDL 72527. | Seiler, N., et al. 2002. Prog Drug Res. 59: 1-40. PMID: 12458962
- Cytotoxic effects of the polyamine oxidase inactivator MDL 72527 to two human colon carcinoma cell lines SW480 and SW620. | Duranton, B., et al. 2002. Cell Biol Toxicol. 18: 381-96. PMID: 12484549
- Inhibition of murine N1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL 72527. | Wu, T., et al. 2005. Biochem Biophys Res Commun. 326: 483-90. PMID: 15582603
- Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: comparison with a saturated structural analogue. | Seiler, N., et al. 2005. Int J Oncol. 27: 1669-76. PMID: 16273223
- Interaction of bovine serum amine oxidase with the polyamine oxidase inactivator MDL 72527. | Agostinelli, E., et al. 2006. Biochem Biophys Res Commun. 340: 840-4. PMID: 16380084
- Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. | Gossé, F., et al. 2006. Int J Oncol. 29: 423-8. PMID: 16820885
- Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. | Agostinelli, E., et al. 2006. Biochim Biophys Acta. 1763: 1040-50. PMID: 16962187
- MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells. | Agostinelli, E., et al. 2007. Biochem Soc Trans. 35: 343-8. PMID: 17371275
- Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. | Agostinelli, E., et al. 2009. Int J Oncol. 35: 485-98. PMID: 19639169
- Effect of Lysosomotropic Polyamineoxidase Inhibitor MDL-72527 on Platelet Activation. | Liu, G., et al. 2016. Cell Physiol Biochem. 38: 1695-702. PMID: 27160671
- Treatment with MDL 72527 Ameliorated Clinical Symptoms, Retinal Ganglion Cell Loss, Optic Nerve Inflammation, and Improved Visual Acuity in an Experimental Model of Multiple Sclerosis. | Liu, F., et al. 2022. Cells. 11: PMID: 36552864
- Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. | Doğan, A., et al. 1999. J Neurochem. 72: 765-70. PMID: 9930751
Inhibitor of:
AdoMetDC, ODC, PAO, PAOX, SATL1, SPDSY, SSAT, and SSAT2.Activator of:
PAO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDL 72527, 1 mg | sc-295375C | 1 mg | $45.00 | |||
MDL 72527, 5 mg | sc-295375B | 5 mg | $132.00 | |||
MDL 72527, 10 mg | sc-295375 | 10 mg | $201.00 | |||
MDL 72527, 25 mg | sc-295375D | 25 mg | $391.00 | |||
MDL 72527, 50 mg | sc-295375A | 50 mg | $750.00 |