Molecular structure of MDL-28170, CAS Number: 88191-84-8
MDL-28170 (CAS 88191-84-8)
See product citations (20)
Alternate Names:
MDL-28170 is also known as Calpain Inhibitor III.
Application:
MDL-28170 is a cell permeable, selective inhibitor of µ-calpain (calpain-1) and m-calpain (calpain-2).
CAS Number:
88191-84-8
Purity:
≥95%
Molecular Weight:
382.45
Molecular Formula:
C22H26N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MDL-28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent cysteine protease which has been implicated in apoptosis of immune cells as well as neuronal cells. It also inhibits cathepsin B. Additionally, MDL-28170 may act to be able to cross the blood-brain barrier and inhibit brain cysteine protease activity, therefore potentially protecting against cortical neuronal damage. It is also proven to prevent anoxia in murine optic nerves. MDL-28170 may act to attenuate depression in myocardial contractile performance that occurs during reperfusion following cardiac ischemia.
MDL-28170 (CAS 88191-84-8) References
- Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells. | Ray, SK., et al. 2000. Brain Res. 852: 326-34. PMID: 10678759
- Calpain inhibitors confer biochemical, but not electrophysiological, protection against anoxia in rat optic nerves. | Jiang, Q. and Stys, PK. 2000. J Neurochem. 74: 2101-7. PMID: 10800955
- Calpain inhibitor MDL 28170 protects hypoxic-ischemic brain injury in neonatal rats by inhibition of both apoptosis and necrosis. | Kawamura, M., et al. 2005. Brain Res. 1037: 59-69. PMID: 15777753
- Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. | Ai, J., et al. 2007. J Neurotrauma. 24: 960-78. PMID: 17600513
- MDL-28170 has no analgesic effect on CCI induced neuropathic pain in mice. | Uçeyler, N., et al. 2010. Molecules. 15: 3038-47. PMID: 20657463
- Calpain inhibitor MDL 28170 protects against the Ca2+ paradox in rat hearts. | Bi, SH., et al. 2012. Clin Exp Pharmacol Physiol. 39: 385-92. PMID: 22356295
- Calpain inhibitor, MDL 28170 confer electrophysiological, nociceptive and biochemical improvement in diabetic neuropathy. | Kharatmal, SB., et al. 2015. Neuropharmacology. 97: 113-21. PMID: 26087461
- Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging mice. | Qiu, LL., et al. 2020. J Neuroinflammation. 17: 23. PMID: 31948437
- Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. | Riva, L., et al. 2020. Nature. 586: 113-119. PMID: 32707573
- CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage. | Liu, Y., et al. 2021. Stroke. 52: 1809-1821. PMID: 33874744
- Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: involvement of calcium-activated proteases. | Chard, PS., et al. 1995. Neuroscience. 65: 1099-108. PMID: 7617165
- Calpain inhibitors block Ca(2+)-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. | Song, DK., et al. 1994. J Neurosci Res. 39: 474-81. PMID: 7884824
- MDL-28170, a membrane-permeant calpain inhibitor, attenuates stunning and PKC epsilon proteolysis in reperfused ferret hearts. | Urthaler, F., et al. 1997. Cardiovasc Res. 35: 60-7. PMID: 9302348
- Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. | Li, PA., et al. 1998. Neurosci Lett. 247: 17-20. PMID: 9637399
Inhibitor of:
2310051M13Rik, Apoptosis, C1orf201, Calpain, Calpain 1, Calpain 15_Solh, Calpain 2, Calpain II, CAP2, Cathepsin, cathepsin A, cathepsin B, cathepsin L, CPAMD8, cystatin SN, dystrophin, EPDR1, ERp27, FAM162B, Gamma-secretase, Kex2, PERP (p53 apoptosis effector related to PMP22), stefin A1L1, stefin A2l1, and stefin A3L1.Activator of:
Calpain II, and cystatin 9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDL-28170, 10 mg | sc-201301 | 10 mg | $68.00 | |||
MDL-28170, 50 mg | sc-201301A | 50 mg | $236.00 | |||
MDL-28170, 100 mg | sc-201301B | 100 mg | $438.00 | |||
MDL-28170, 500 mg | sc-201301C | 500 mg | $2152.00 |