Molecular structure of MDL-27,032, CAS Number: 110124-55-5
MDL-27,032 (CAS 110124-55-5)
Alternate Names:
4-Propyl-5-(4-pyridinyl)-2(3H)-oxazolone
Application:
MDL-27,032 is a PKA and PKC inhibitor
CAS Number:
110124-55-5
Molecular Weight:
204.23
Molecular Formula:
C11H12N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MDL-27,032 is a potent vasodilator and cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) inhibitor. This inhibition is competitive with ATP, but not, however, with phospholipid, diacylglycerol, phorbol ester or calcium.
MDL-27,032 (CAS 110124-55-5) References
- Inhibition of angiogenesis in vitro and in ovo with an inhibitor of cellular protein kinases, MDL 27032. | Wright, PS., et al. 1992. J Cell Physiol. 152: 448-57. PMID: 1380511
- Differential stimulation of protein kinase C activity by phorbol ester or calcium/phosphatidylserine in vitro and in intact synaptosomes. | Robinson, PJ. 1992. J Biol Chem. 267: 21637-44. PMID: 1400474
- MDL 27,032 relaxes vascular smooth muscle and inhibits protein kinase C. | Cheng, HC., et al. 1991. J Cardiovasc Pharmacol. 17: 445-55. PMID: 1711607
- Inhibition of experimental metastasis and cell adhesion of B16F1 melanoma cells by inhibitors of protein kinase C. | Dumont, JA., et al. 1992. Cancer Res. 52: 1195-200. PMID: 1737379
- Effects of inhibitors of protein kinase C and phosphodiesterase on the contractile effects of endothelin in dog femoral artery. | Cheng, HC. and Dage, RC. 1991. Neurochem Int. 18: 497-501. PMID: 20504732
- MDL 27,032 [4-propyl-5-(4-pyridinyl)-2(3H)-oxazolone], an active site-directed inhibitor of protein kinase C and cyclic AMP-dependent protein kinase that relaxes vascular smooth muscle. | Robinson, PJ., et al. 1990. J Pharmacol Exp Ther. 255: 1392-8. PMID: 2175806
- Isolation of a novel collagen-binding protein from the mushroom, Hypsizigus marmoreus, which inhibits the Lewis lung carcinoma cell adhesion to type IV collagen. | Tsuchida, K., et al. 1995. J Biol Chem. 270: 1481-4. PMID: 7829472
- Vasoconstrictors inhibit ATP-sensitive K+ channels in arterial smooth muscle through protein kinase C. | Bonev, AD. and Nelson, MT. 1996. J Gen Physiol. 108: 315-23. PMID: 8894979
- Synthesis and biological evaluation of monoindolyl and indolocarbazolyl oxazolones and imidazolones. | Pereira, ER., et al. 1997. Chem Pharm Bull (Tokyo). 45: 733-6. PMID: 9145508
- A short synthesis of an indolocarbazolyl-oxazol-2-one, a potential protein kinase C inhibitor | Pereira, E. R., & Prudhomme, M. 1995. Tetrahedron letters. 36(14): 2477-2478.
Inhibitor of:
PKA, PKC, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDL-27,032, 100 µg | sc-205953 | 100 µg | $200.00 | |||
MDL-27,032, 1 mg | sc-205953A | 1 mg | $400.00 |