MDL 11,939 (CAS 107703-78-6)
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MDL 11,939 is a potent, selective SR-2 antagonist (Ki values are 0.54 and 81.6 nM at SR-2A and SR-2C, respectively). Antagonists like MDL 11,939 bind to these receptors without activating them, effectively blocking the action of serotonin (a neurotransmitter) and other agonistic substances. Selectivity: The structural design of MDL 11,939 enhances its selectivity for the 5-HT2A receptor, making it useful for dissecting the specific contributions of this receptor subtype in physiological and pathological processes. Researchers use MDL 11,939 to study the binding characteristics and specificity of the 5-HT2A receptor. By examining how this compound interacts with the receptor at a molecular level, insights can be gained into the receptor′s role in cell signaling pathways.
MDL 11,939 (CAS 107703-78-6) References
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- Effects of MDL 11,939 on action potential and contractile force in cardiac tissues: a comparison with bretylium, clofilium, and sotalol. | Li, T., et al. 1990. J Cardiovasc Pharmacol. 16: 917-23. PMID: 1704984
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- 5-HT2A receptor antagonism by MDL 11,939 during inescapable stress prevents subsequent exaggeration of acoustic startle response and reduced body weight in rats. | Jiang, X., et al. 2011. J Psychopharmacol. 25: 289-97. PMID: 19889890
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDL 11,939, 5 mg | sc-204069 | 5 mg | $172.00 | |||
MDL 11,939, 50 mg | sc-204069A | 50 mg | $1255.00 |