MDL 105,212 hydrochloride is a non-peptide tachykinin antagonist that has high affinity for NK1 and NK2 receptors.
Identification and chemical synthesis of MDL 105,212, a non-peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors: T.P. Burkholder, et al.; Bioorg. Med. Chem. Lett. 6, 951 (1996) In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist: E.M. Kudlacz, et al.; J. Pharmacol. Exp. Ther. 277, 840 (1996) Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model: E.M. Kudlacz, et al.; J. Pharmacol. Exp. Ther. 279, 732 (1996)
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