MDGI Antibody (6B6): sc-52073
- MDGI Antibody (6B6) is a mouse monoclonal IgG2b provided at 100 µg/ml
- raised against human mammary-derived growth inhibitor
- recommended for detection of MDGI of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MDGI Antibody (6B6). This work is in progress.
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MDGI Antibody (6B6) is a mouse monoclonal IgG2b antibody that detects MDGI in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Mammary-derived growth inhibitor (MDGI), also known as Fatty Acid-Binding Protein 3 (FABP3), plays a crucial role in the transport and metabolism of fatty acids within cardiac and skeletal muscle tissues, which is vital for maintaining energy homeostasis and cellular function. Anti-MDGI antibody (6B6) enables researchers to study MDGI′s ability to bind and transport fatty acids, which provides necessary substrates for energy production, particularly during periods of increased metabolic demand, such as exercise or stress. MDGI is involved in the regulation of lipid metabolism and has been implicated in various pathological conditions, including cardiovascular diseases and metabolic disorders. MDGI expression is notably high in the myocardium and muscle fibers, highlighting its importance in these tissues. Anti-MDGI antibody (6B6) serves as an invaluable tool for researchers studying lipid metabolism and related diseases, enabling the exploration of MDGI′s role in health and disease.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MDGI Antibody (6B6) References:
- Modulation of the beta-adrenergic-response in cultured rat heart cells. II. Mammary-derived growth inhibitor (MDGI) blocks induction of beta-adrenergic supersensitivity. Dissociation from lipid-binding activity of MDGI. | Wallukat, G., et al. 1991. Mol Cell Biochem. 102: 49-60. PMID: 1646956
- Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion. | Nevo, J., et al. 2010. Oncogene. 29: 6452-63. PMID: 20802519
- Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas. | Meseure, D., et al. 2020. Anal Cell Pathol (Amst). 2020: 9268236. PMID: 32377505
- Tumor-Targeting Peptides: The Functional Screen of Glioblastoma Homing Peptides to the Target Protein FABP3 (MDGI). | Ayo, A., et al. 2020. Cancers (Basel). 12: PMID: 32650473
- Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3. | Liu, ZZ., et al. 2021. Autophagy. 17: 2766-2782. PMID: 33143524
- FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging. | Lee, SM., et al. 2020. Nat Commun. 11: 5661. PMID: 33168829
- FABP3 overexpression promotes vascular fibrosis in Takayasu's arteritis by enhancing fatty acid oxidation in aorta adventitial fibroblasts. | Wu, S., et al. 2022. Rheumatology (Oxford). 61: 3071-3081. PMID: 34718429
- The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3. | Chen, S., et al. 2024. J Lipid Res. 65: 100499. PMID: 38218337
- FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury. | Zhong, FF., et al. 2024. Neurotox Res. 42: 35. PMID: 39008165
- Dinucleotide repeat in the third intron of the FABP3/MDGI putative tumor suppressor gene. | Arlt, MF., et al. 1996. Dis Markers. 13: 57-9. PMID: 8875119
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDGI Antibody (6B6) | sc-52073 | 100 µg/ml | $322.00 |