MDGI Antibody (1rFABP-299): sc-81750

MDGI Antibody (1rFABP-299) is a mouse monoclonal IgG1 antibody that detects MDGI in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Mammary-derived growth inhibitor (MDGI), also known as Fatty Acid-Binding Protein 3 (FABP3), plays a crucial role in the transport and metabolism of fatty acids within cardiac and skeletal muscle tissues, which is vital for maintaining energy homeostasis and supporting cellular functions. Anti-MDGI antibody (1rFABP-299) recognizes a protein essential for various metabolic processes, including lipid metabolism and energy production, particularly during periods of increased energy demand, such as exercise or stress. MDGI is highly expressed in the myocardium and is involved in the regulation of fatty acid uptake, which can influence cardiac function and overall metabolic health. MDGI presence in the cytoplasm of muscle cells allows for efficient fatty acid transport to mitochondria, where they are oxidized for energy, highlighting its importance in both normal physiology and potential pathophysiological conditions, such as heart disease. MDGI monoclonal antibody (1rFABP-299) serves as an invaluable tool for researchers investigating the roles of fatty acid-binding proteins in metabolic regulation and related disorders.

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MDGI Antibody (1rFABP-299) References:

1. Investigation of porcine FABP3 and LEPR gene polymorphisms and mRNA expression for variation in intramuscular fat content.  |  Li, X., et al. 2010. Mol Biol Rep. 37: 3931-9. PMID: 20300864
2. Fabp3 inhibits proliferation and promotes apoptosis of embryonic myocardial cells.  |  Zhu, C., et al. 2011. Cell Biochem Biophys. 60: 259-66. PMID: 21293949
3. Silencing of FABP3 promotes apoptosis and induces mitochondrion impairment in embryonic carcinoma cells.  |  Shen, YH., et al. 2012. J Bioenerg Biomembr. 44: 317-23. PMID: 22528395
4. Overexpression of FABP3 promotes apoptosis through inducing mitochondrial impairment in embryonic cancer cells.  |  Song, GX., et al. 2012. J Cell Biochem. 113: 3701-8. PMID: 22753283
5. The circulating level of FABP3 is an indirect biomarker of microRNA-1.  |  Varrone, F., et al. 2013. J Am Coll Cardiol. 61: 88-95. PMID: 23141496
6. Response of different mammary epithelial cell lines to a mammary derived growth inhibitor (MDGI).  |  Lehmann, W., et al. 1989. Biomed Biochim Acta. 48: 143-51. PMID: 2775246
7. A polypeptide growth inhibitor isolated from lactating bovine mammary gland (MDGI) is a lipid-carrying protein.  |  Böhmer, FD., et al. 1988. J Cell Biochem. 38: 199-204. PMID: 3230093
8. Antibodies against mammary derived growth inhibitor (MDGI) react with a fibroblast growth inhibitor and with heart fatty acid binding protein.  |  Böhmer, FD., et al. 1987. Biochem Biophys Res Commun. 148: 1425-31. PMID: 3318832
9. Amelioration of Nicotine-Induced Conditioned Place Preference Behaviors in Mice by an FABP3 Inhibitor.  |  Jia, W., et al. 2023. Int J Mol Sci. 24: PMID: 37047614
10. Autophagy regulates age-related delayed jawbone regeneration and decreased osteoblast osteogenesis by degrading FABP3.  |  Xu, Y., et al. 2024. FASEB J. 38: e23824. PMID: 39012304

The preferred B-FABP antibody is B-FABP Antibody (F-6): sc-374588.