MCT4 Antibody (G-7): sc-376465

MCT4 Antibody (G-7) is a mouse monoclonal IgG3 kappa light chain antibody engineered to detect Monocarboxylate Transporter 4 (MCT4) in mouse, rat, and human species across various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-MCT4 antibody (G-7) specifically targets amino acids 376-465 within the C-terminal cytoplasmic domain of human MCT4, ensuring precise binding and reliable detection. MCT4 is a member of the solute carrier 16A (SLC16A) family of proteins, and is an integral membrane protein predominantly localized to the plasma membrane. MCT4 plays a crucial role in transporting lactate and other monocarboxylates out of cells, maintaining intracellular pH balance and enabling sustained glycolysis, particularly in highly glycolytic tissues such as skeletal muscle and cancer cells exhibiting the Warburg effect. Structurally, MCT4 consists of 10-12 transmembrane-helical domains with both amino and carboxy termini located in the cytoplasm, facilitating function as a proton symporter. MCT4 undergoes post-translational modifications, notably N-glycosylation, which are essential for proper folding, stability, and trafficking to the plasma membrane. These modifications ensure functional integrity of MCT4, allowing efficient lactate export and contribution to cellular metabolism and survival under anaerobic conditions. Strategic localization and structural integrity of MCT4 make this protein a key player in metabolic flexibility and a significant target for research into cancer metabolism and other diseases characterized by altered lactate transport. MCT4 (G-7) antibody is available in non-conjugated form, providing versatility for diverse experimental setups. Anti-MCT4 antibody (G-7) is an invaluable tool for researchers studying expression, localization, post-translational modifications, and functional roles of MCT4 in various physiological and pathological contexts, facilitating advancements in understanding cellular metabolism and developing potential therapeutic interventions.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MCT4 Antibody (G-7) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-MCT4 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MCT4 Antibody (G-7) Specifications

Alternate Product Name: SLC16A3

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 376-465

Epitope Target: MCT4

Epitope Species: human

Product Reactivity/Detection: MCT4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for MCT4 Antibody (G-7): N/A

The preferred MCT4 antibody is MCT4 Antibody (D-1): sc-376140.