MCT13 Antibody (D-12): sc-377128
- MCT13 Antibody (D-12) is a mouse monoclonal IgG1 κ MCT13 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 351-381 within a cytoplasmic domain of MCT13 of human origin
- MCT13 Antibody (D-12) is recommended for detection of MCT13 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-MCT13 Antibody (D-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for MCT13 Antibody (D-12) for WB applications. This reagent is now offered in a bundle with MCT13 Antibody (D-12) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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MCT13 Antibody (D-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects MCT13 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MCT13 (D-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MCT13, also known as SLC16A13, is a 426 amino acid multi-pass membrane protein that plays a crucial role in cellular metabolism by facilitating the transport of monocarboxylates, such as lactate and pyruvate, across the plasma membrane. This transport is vital because lactic acid, produced during glycolysis, can accumulate and lower intracellular pH, inhibiting glycolysis and ATP production. MCT13 functions as a proton-linked monocarboxylate transporter, ensuring that lactate is efficiently removed from the cell to maintain metabolic homeostasis and support continued energy production. The ability of MCT13 to transport L-lactate is particularly important in tissues with high metabolic demands, such as muscle and brain, where rapid shifts in energy substrates are necessary during periods of intense activity or stress.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MCT13 Antibody (D-12) References:
- The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. | Halestrap, AP. and Meredith, D. 2004. Pflugers Arch. 447: 619-28. PMID: 12739169
- Monocarboxylate transporters (MCT) as lactate carriers in equine muscle and red blood cells. | Koho, NM., et al. 2006. Equine Vet J Suppl. 354-8. PMID: 17402447
- PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine. | Hirai, T., et al. 2007. Biol Pharm Bull. 30: 2185-90. PMID: 17978498
- Mitochondrial lactate oxidation complex and an adaptive role for lactate production. | Hashimoto, T. and Brooks, GA. 2008. Med Sci Sports Exerc. 40: 486-94. PMID: 18379211
- Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. | Morris, ME. and Felmlee, MA. 2008. AAPS J. 10: 311-21. PMID: 18523892
- The SLC16 monocaboxylate transporter family. | Meredith, D. and Christian, HC. 2008. Xenobiotica. 38: 1072-106. PMID: 18668440
- Evidence for the mitochondrial lactate oxidation complex in rat neurons: demonstration of an essential component of brain lactate shuttles. | Hashimoto, T., et al. 2008. PLoS One. 3: e2915. PMID: 18698340
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCT13 Antibody (D-12) | sc-377128 | 200 µg/ml | $322.00 | |||
MCT13 Antibody (D-12): m-IgGκ BP-HRP Bundle | sc-523203 | 200 µg Ab, 40 µg BP | $361.00 | |||
MCT13 Antibody (D-12) AC | sc-377128 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MCT13 Antibody (D-12) HRP | sc-377128 HRP | 200 µg/ml | $322.00 | |||
MCT13 Antibody (D-12) FITC | sc-377128 FITC | 200 µg/ml | $336.00 | |||
MCT13 Antibody (D-12) PE | sc-377128 PE | 200 µg/ml | $349.00 | |||
MCT13 Antibody (D-12) Alexa Fluor® 488 | sc-377128 AF488 | 200 µg/ml | $364.00 | |||
MCT13 Antibody (D-12) Alexa Fluor® 546 | sc-377128 AF546 | 200 µg/ml | $364.00 | |||
MCT13 Antibody (D-12) Alexa Fluor® 594 | sc-377128 AF594 | 200 µg/ml | $364.00 | |||
MCT13 Antibody (D-12) Alexa Fluor® 647 | sc-377128 AF647 | 200 µg/ml | $364.00 | |||
MCT13 Antibody (D-12) Alexa Fluor® 680 | sc-377128 AF680 | 200 µg/ml | $364.00 | |||
MCT13 Antibody (D-12) Alexa Fluor® 790 | sc-377128 AF790 | 200 µg/ml | $364.00 | |||
MCT13 (D-12) Neutralizing Peptide | sc-377128 P | 100 µg/0.5 ml | $69.00 |