Molecular structure of McN-A-343, CAS Number: 55-45-8
McN-A-343 (CAS 55-45-8)
See product citations (4)
Alternate Names:
(4-Hydroxy-2-butynyl)-1-trimethylammonium-3-chlorocarbanilate chloride
CAS Number:
55-45-8
Purity:
99%
Molecular Weight:
317.2
Molecular Formula:
C14H18ClN2O2•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
McN-A-343 is selective agonist of the muscarinic M1 receptor. McN-A-343 has been used to probe the identity of muscarinic receptors responsible for contractile and relaxant response mediation in various biological systems. Agonist activity at the muscarinic M4 receptor is also described with McN-A-343.
McN-A-343 (CAS 55-45-8) References
- Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M1 receptors. | Davies, RH., et al. 2001. J Pharm Pharmacol. 53: 487-96. PMID: 11341365
- Presynaptic muscarinic M(2)-receptor-mediated inhibition of N-type Ca(2+) channels in cultured sphenopalatine ganglion: direct evidence for acetylcholine inhibition of cerebral nitrergic neurogenic vasodilation. | Liu, J., et al. 2002. J Pharmacol Exp Ther. 302: 397-405. PMID: 12065743
- M1 receptor-mediated nitric oxide-dependent relaxation unmasked in stomach fundus from M3 receptor knockout mice. | Stengel, PW. and Cohen, ML. 2003. J Pharmacol Exp Ther. 304: 675-82. PMID: 12538821
- Protein kinase A and Ca(v)1 (L-Type) channels are common targets to facilitatory adenosine A2A and muscarinic M1 receptors on rat motoneurons. | Oliveira, L. and Correia-de-Sá, P. 2005. Neurosignals. 14: 262-72. PMID: 16301841
- Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors. | May, LT., et al. 2007. Mol Pharmacol. 72: 463-76. PMID: 17525129
- Heterogeneity of muscarinic receptor-mediated Ca2+ responses in cultured urothelial cells from rat. | Kullmann, FA., et al. 2008. Am J Physiol Renal Physiol. 294: F971-81. PMID: 18272602
- Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes. | Figueroa, KW., et al. 2009. J Pharmacol Exp Ther. 328: 331-42. PMID: 18824613
- Cholinergic modulation of neuronal excitability in the rat suprachiasmatic nucleus. | Yang, JJ., et al. 2010. J Neurophysiol. 103: 1397-409. PMID: 20071625
- Mutagenesis of nucleophilic residues near the orthosteric binding pocket of M1 and M2 muscarinic receptors: effect on the binding of nitrogen mustard analogs of acetylcholine and McN-A-343. | Suga, H., et al. 2010. Mol Pharmacol. 78: 745-55. PMID: 20643905
- The pharmacology of McN-A-343. | Mitchelson, FJ. 2012. Pharmacol Ther. 135: 216-45. PMID: 22643681
- The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva). | Zhong, W. and Darmani, NA. 2020. Neurochem Int. 132: 104603. PMID: 31738972
- The M1 muscarinic acetylcholine receptor in the crypt stem cell compartment mediates intestinal mucosal growth. | Greig, CJ., et al. 2020. Exp Biol Med (Maywood). 245: 1194-1199. PMID: 32611198
- M1 acetylcholine receptor stimulation increases the extracellular concentrations of glutamate and GABA in the medial prefrontal cortex of the rat. | Sanz, B., et al. 1997. Neurochem Res. 22: 281-6. PMID: 9051662
- M1 muscarinic receptor stimulation decreases aspartate release in the rat neostriatum. | Expósito, I., et al. 1997. Neurochem Res. 22: 1485-90. PMID: 9357014
Activator of:
mAChR M1, and mAChR M2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
McN-A-343, 10 mg | sc-200186A | 10 mg | $27.00 | |||
McN-A-343, 50 mg | sc-200186 | 50 mg | $79.00 |