Molecular structure of MCC950 sodium salt, CAS Number: 256373-96-3
MCC950 sodium salt (CAS 256373-96-3)
See product citations (3)
Alternate Names:
CP-456773 sodium salt
CAS Number:
256373-96-3
Molecular Weight:
426.50
Molecular Formula:
C20H23N2NaO5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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MCC950 sodium is a small molecule that inhibits the NLRP3 inflammasome, a player in controlling inflammation. NLRP3 is an intracellular protein complex pivotal in managing inflammation. Upon activation, NLRP3 forms an inflammasome, which in turn initiates the release of pro-inflammatory cytokines. MCC950 sodium interrupts the activation of NLRP3, thus stopping the inflammasome formation and subsequently diminishing inflammation.
MCC950 sodium salt (CAS 256373-96-3) References
- Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain. | Khan, N., et al. 2018. Inflammopharmacology. 26: 77-86. PMID: 28965161
- NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-κB. | Zhang, WJ., et al. 2019. Parasit Vectors. 12: 29. PMID: 30635040
- MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. | Coll, RC., et al. 2019. Nat Chem Biol. 15: 556-559. PMID: 31086327
- NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma. | Lu, F., et al. 2021. Cancer Lett. 497: 178-189. PMID: 33091534
- Enduring glucocorticoid-evoked exacerbation of synaptic plasticity disruption in male rats modelling early Alzheimer's disease amyloidosis. | Qi, Y., et al. 2021. Neuropsychopharmacology. 46: 2170-2179. PMID: 34188184
- MCC950 attenuates doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis. | Zhang, L., et al. 2021. Biomed Pharmacother. 143: 112133. PMID: 34474337
- METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA. | Meng, L., et al. 2022. Cell Death Dis. 13: 38. PMID: 35013106
- Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction. | Wang, H., et al. 2022. Cell Death Dis. 13: 281. PMID: 35351877
- Inhibition of NLRP3 inflammasome-mediated neuroinflammation alleviates electroconvulsive shock-induced memory impairment via regulation of hippocampal synaptic plasticity in depressive rats. | Liu, D., et al. 2022. Behav Brain Res. 428: 113879. PMID: 35390431
- Mussel-Inspired Microgel Encapsulated NLRP3 Inhibitor as a Synergistic Strategy Against Dry Eye. | Zha, Z., et al. 2022. Front Bioeng Biotechnol. 10: 913648. PMID: 35721850
- The pro-inflammatory effect of Staphylokinase contributes to community-associated Staphylococcus aureus pneumonia. | Wang, Y., et al. 2022. Commun Biol. 5: 618. PMID: 35739262
- Process of Glucose Increases Rather Than Constant High Glucose Was the Main Cause of Abnormal Glucose Induced Glomerulus Epithelial Cells Inflammatory Response. | Qi, J., et al. 2022. Int J Mol Sci. 24: PMID: 36614042
- In vitro evaluation of a hybrid drug-delivery nanosystem for fibrosis prevention in cell therapy for Type 1 diabetes. | Rennie, C., et al. 2023. Nanomedicine (Lond). 18: 53-66. PMID: 36938861
- Low expression of miR-1929-3p mediates murine cytomegalovirus-induced fibrosis in cardiac fibroblasts via targeting endothelin a receptor/NLRP3 inflammasome pathway. | Li, J., et al. 2023. In Vitro Cell Dev Biol Anim.. PMID: 37002490
Inhibitor of:
gasdermin, gasdermin A2, gasdermin A3, ICE-LAP6, NAIP1, NALP10, NALP2, NALP4, NALP4E, NALP5, NALP7, NALP8, NALP9B, PAC2, PHTF1, RICK, RIPK, and TNP2.Activator of:
β8 Tubulin, C1q, C9orf116, caspase-1, EML2, IFN-α10, and ZBP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MCC950 sodium salt, 5 mg | sc-505904 | 5 mg | $114.00 | |||
MCC950 sodium salt, 10 mg | sc-505904A | 10 mg | $198.00 | |||
MCC950 sodium salt, 50 mg | sc-505904B | 50 mg | $888.00 | |||
MCC950 sodium salt, 100 mg | sc-505904C | 100 mg | $1569.00 |