Date published: 2026-1-9

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MC1-R Antibody (578CT6.2.3): sc-517344

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Datasheets
  • MC1-R Antibody (578CT6.2.3) is a mouse monoclonal IgM MC1-R antibody provided at 100 µg/ml
  • raised against a synthetic peptide corresponding to amino acids 205-232 in a central region of MC1-R of human origin
  • recommended for detection of MC1-R of human origin by WBIP
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MC1-R Antibody (578CT6.2.3). This work is in progress.

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    MC1-R Antibody (578CT6.2.3) is a mouse monoclonal IgM antibody that detects MC1-R protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-MC1-R antibody (578CT6.2.3) is available as a non-conjugated format, specifically targeting melanocortin-1 receptor (MC1-R), which plays a crucial role in regulating pigmentation in melanocytes. MC1-R (578CT6.2.3) antibody recognizes a receptor essential for melanin production, the pigment responsible for skin and hair color, and activation can influence various physiological processes, including UV radiation response. MC1-R (578CT6.2.3) monoclonal antibody targets proteins primarily located on melanocyte surfaces, where MC1-R interacts with melanocyte-stimulating hormones to modulate melanin synthesis. Understanding MC1-R function and location is vital, as dysregulation can lead to conditions such as skin cancer and pigmentation disorders. The melanocortin family, which includes α-, β-, and γ-melanocyte stimulating hormones, interacts with five different receptors, each exhibiting unique expression patterns and affinities. MC1-R is particularly significant due to its role in the skin′s protective response to environmental stressors, making MC1-R a key target for research in dermatology and oncology.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    MC1-R Antibody (578CT6.2.3) References:

    1. The cloning of a family of genes that encode the melanocortin receptors.  |  Mountjoy, KG., et al. 1992. Science. 257: 1248-51. PMID: 1325670
    2. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA.  |  Chhajlani, V. and Wikberg, JE. 1992. FEBS Lett. 309: 417-20. PMID: 1516719
    3. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.  |  Mountjoy, KG., et al. 1994. Mol Endocrinol. 8: 1298-308. PMID: 7854347
    4. Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues.  |  Labbé, O., et al. 1994. Biochemistry. 33: 4543-9. PMID: 8161509
    5. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor.  |  Gantz, I., et al. 1993. J Biol Chem. 268: 15174-9. PMID: 8392067
    6. Molecular cloning of a novel human melanocortin receptor.  |  Chhajlani, V., et al. 1993. Biochem Biophys Res Commun. 195: 866-73. PMID: 8396929
    7. Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.  |  Roselli-Rehfuss, L., et al. 1993. Proc Natl Acad Sci U S A. 90: 8856-60. PMID: 8415620
    8. Molecular cloning of a novel melanocortin receptor.  |  Gantz, I., et al. 1993. J Biol Chem. 268: 8246-50. PMID: 8463333

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    MC1-R Antibody (578CT6.2.3)

    sc-517344
    100 µg/ml
    $322.00