Molecular structure of MC 1568, CAS Number: 852475-26-4
MC 1568 (CAS 852475-26-4)
See product citations (4)
Alternate Names:
3-[5-(3-(3-Fluorophenyl)-3-oxoprope n-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-prope namide
Application:
MC 1568 is a class II (IIa) HDAC inhibitor selective for HDAC4 and HDAC6
CAS Number:
852475-26-4
Purity:
≥95%
Molecular Weight:
314.31
Molecular Formula:
C17H15FN2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MC 1568 is a class II (IIa) HDAC inhibitor selective for HDAC4 and HDAC6 (IC50 = 220 nM). MC 1568 also inhibits HDAC5. MC 1568 are a group of enzymes responsible for epigenetic control of gene expression, influencing diverse biological functions such as cell differentiation, proliferation, inflammation, and development. Scientific investigations have harnessed MC 1568 for various research applications.
MC 1568 (CAS 852475-26-4) References
- Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells. | Venza, I., et al. 2013. Pigment Cell Melanoma Res. 26: 193-204. PMID: 23176534
- Improved synthesis and structural reassignment of MC1568: a class IIa selective HDAC inhibitor. | Fleming, CL., et al. 2014. J Med Chem. 57: 1132-5. PMID: 24450497
- Class IIa histone deacetylases affect neuronal remodeling and functional outcome after stroke. | Kassis, H., et al. 2016. Neurochem Int. 96: 24-31. PMID: 27103167
- MC1568 Inhibits Thimerosal-Induced Apoptotic Cell Death by Preventing HDAC4 Up-Regulation in Neuronal Cells and in Rat Prefrontal Cortex. | Guida, N., et al. 2016. Toxicol Sci. 154: 227-240. PMID: 27660204
- MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: role of Hsp90 acetylation. | Panella, S., et al. 2016. Future Med Chem. 8: 2017-2031. PMID: 27739328
- Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice. | Lapucci, A., et al. 2017. Neurosci Lett. 656: 120-125. PMID: 28732762
- Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway. | Saito, S., et al. 2017. PLoS One. 12: e0186615. PMID: 29045477
- MC1568 Enhances Histone Acetylation During Oocyte Meiosis and Improves Development of Somatic Cell Nuclear Transfer Embryos in Pig. | Wang, H., et al. 2018. Cell Reprogram. 20: 55-65. PMID: 29412739
- MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation. | Daneshpajooh, M., et al. 2018. Acta Diabetol. 55: 1231-1235. PMID: 30088095
- Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis. | Xiong, C., et al. 2019. FASEB J. 33: 8249-8262. PMID: 30951378
- Peripheral administration of the Class-IIa HDAC inhibitor MC1568 partially protects against nigrostriatal neurodegeneration in the striatal 6-OHDA rat model of Parkinson's disease. | Mazzocchi, M., et al. 2022. Brain Behav Immun. 102: 151-160. PMID: 35217173
- Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury. | He, X., et al. 2022. Front Med (Lausanne). 9: 848938. PMID: 35492337
- Celastrol inhibits lung cancer growth by triggering histone acetylation and acting synergically with HDAC inhibitors. | Chen, G., et al. 2022. Pharmacol Res. 185: 106487. PMID: 36202184
Inhibitor of:
HDAC10, HDAC4, HDAC5, HDAC6, Histone cluster 1 H2AB, OTTMUSG00000010747, SIRT1, and SIRT3.Activator of:
SCML1, Sir4, and TBL1Y.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MC 1568, 10 mg | sc-362767 | 10 mg | $179.00 | |||
MC 1568, 50 mg | sc-362767A | 50 mg | $566.00 |