MBP Antibody (201): sc-66064
- MBP Antibody (201) is a mouse monoclonal IgG2b, cited in 11 publications, provided at 100 µg/ml
- raised against amino acids 130-136 of MBP of human origin
- recommended for detection of MBP (human 21.5 kDa and 18.5 kDa molecular forms) of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including and rabbit, ovine, caprine and primate
- See MBP (F-6): sc-271524 for MBP antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MBP Antibody (201). This work is in progress.
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MBP Antibody (201) is a mouse monoclonal IgG2b antibody that detects myelin basic protein (MBP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. MBP plays a crucial role in the formation and maintenance of the myelin sheath, which insulates nerve fibers and facilitates efficient signal transmission in the central nervous system. MBP′s structure is characterized by its highly basic nature, allowing interaction with negatively charged lipids in the myelin membrane, thereby stabilizing the myelin sheath. This structural integrity is vital for proper neuronal function, as disruptions in myelin can lead to severe neurological disorders, including multiple sclerosis. Furthermore, MBP undergoes post-translational modifications, such as phosphorylation, which are essential for regulating function and stability during myelinogenesis and in response to neuronal activity. Anti-MBP antibody (201) is an invaluable tool for researchers studying myelin-related processes and the underlying mechanisms of demyelinating diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MBP Antibody (201) References:
- Myelin basic protein (MBP) and MBP peptides are mitogens for cultured astrocytes. | South, SA., et al. 2000. Glia. 29: 81-90. PMID: 10594925
- Copper uptake induces self-assembly of 18.5 kDa myelin basic protein (MBP). | Bund, T., et al. 2010. Biophys J. 99: 3020-8. PMID: 21044600
- Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myelin basic protein (MBP) synthesis. | White, R., et al. 2012. J Biol Chem. 287: 1742-54. PMID: 22128153
- Lateral self-assembly of 18.5-kDa myelin basic protein (MBP) charge component-C1 on membranes. | Kattnig, DR., et al. 2012. Biochim Biophys Acta. 1818: 2636-47. PMID: 22728818
- Perturbation of myelin basic protein (Mbp) splice variant expression in developing rat cerebellum following perinatal exposure to methylmercury. | Padhi, BK. and Pelletier, G. 2012. Toxicol Lett. 213: 374-80. PMID: 22835759
- How human IgGs against myelin basic protein (MBP) recognize oligopeptides and MBP. | Belov, S., et al. 2017. J Mol Recognit. 30: PMID: 28470769
- Correlations of quantitative MRI metrics with myelin basic protein (MBP) staining in a murine model of demyelination. | Soustelle, L., et al. 2019. NMR Biomed. 32: e4116. PMID: 31225675
- Myelin basic protein (MBP) charge variants show different sphingomyelin-mediated interactions with myelin-like lipid monolayers. | Widder, K., et al. 2020. Biochim Biophys Acta Biomembr. 1862: 183077. PMID: 31805269
- Effect of Cholesterol and Myelin Basic Protein (MBP) Content on Lipid Monolayers Mimicking the Cytoplasmic Membrane of Myelin. | Träger, J., et al. 2020. Cells. 9: PMID: 32106542
- Ibogaine administration following repeated morphine administration upregulates myelination markers 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin basic protein (MBP) mRNA and protein expression in the internal capsule of Sprague Dawley rats. | Govender, D., et al. 2024. Front Neurosci. 18: 1378841. PMID: 39114487
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MBP Antibody (201) | sc-66064 | 100 µg/ml | $322.00 |