MBD1 Antibody (100B272.1): sc-52901
- MBD1 Antibody (100B272.1) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against synthetic MBD1 of human origin
- recommended for detection of MBD1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MBD1 Antibody (100B272.1). This work is in progress.
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MBD1 Antibody (100B272.1) is a mouse monoclonal IgG1 antibody that detects MBD1 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). MBD1, or methyl-CpG binding protein 1, plays a crucial role in the regulation of gene transcription by binding specifically to methylated DNA, particularly at methyl-CpG sites, which are often found in gene promoter regions. This binding is essential for mediating transcriptional repression, a process that is vital for normal cellular function and development. MBD1′s ability to interact with other proteins, such as histone deacetylases, allows MBD1 to form complexes that further inhibit gene expression, thereby influencing various biological processes including differentiation and response to environmental signals. The expression of MBD1 is predominantly observed in somatic tissues, highlighting MBD1′s importance in maintaining cellular identity and function. Understanding the role of MBD1 in gene regulation is critical, as dysregulation of MBD1 has been implicated in various diseases, including cancer and neurological disorders. Anti-MBD1 antibody (100B272.1) is an invaluable tool for researchers investigating the complex mechanisms of gene expression and the implications of DNA methylation in health and disease.
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MBD1 Antibody (100B272.1) References:
- Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms. | Fujita, N., et al. 1999. Mol Cell Biol. 19: 6415-26. PMID: 10454587
- MCAF mediates MBD1-dependent transcriptional repression. | Fujita, N., et al. 2003. Mol Cell Biol. 23: 2834-43. PMID: 12665582
- Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. | Fujita, N., et al. 2003. J Biol Chem. 278: 24132-8. PMID: 12711603
- Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation. | Sakamoto, Y., et al. 2007. J Biol Chem. 282: 16391-400. PMID: 17428788
- The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation. | Minkovsky, A., et al. 2014. Epigenetics Chromatin. 7: 12. PMID: 25028596
- MBD1 Contributes to the Genesis of Acute Pain and Neuropathic Pain by Epigenetic Silencing of Oprm1 and Kcna2 Genes in Primary Sensory Neurons. | Mo, K., et al. 2018. J Neurosci. 38: 9883-9899. PMID: 30266739
- MBD1 promotes the malignant behavior of gallbladder cancer cells and induces chemotherapeutic resistance to gemcitabine. | Wensheng, L., et al. 2019. Cancer Cell Int. 19: 232. PMID: 31516389
- Assessment of Immuno-Histochemical Expression of MBD1 in Colorectal Adenocarcinoma and Its Correlations with Prognostic Factors. | Ghaedamini, S., et al. 2020. Middle East J Dig Dis. 12: 39-44. PMID: 32082520
- NR2F2-AS1 accelerates cell proliferation through regulating miR-4429/MBD1 axis in cervical cancer. | Liu, D., et al. 2020. Biosci Rep. 40: PMID: 32469064
- LncRNA SNHG20 silencing inhibits hepatocellular carcinoma progression by sponging miR-5095 from MBD1. | Xu, B., et al. 2023. Am J Transl Res. 15: 4314-4331. PMID: 37434830
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MBD1 Antibody (100B272.1) | sc-52901 | 100 µg/ml | $339.00 |