MAZ51 (CAS 163655-37-6)
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MAZ51 is an indole derivative that has been studied for its potential applications in the fields of pharmacology, biochemistry and physiology. It inhibits vascular endothelial cell growth factor-C (VEGF-C)-induced intracellular phosphorylation of Flt-4 (VEGFR-3) (IC50 = 1 muM). MAZ51 has also been identified as a novel, potent and selective inhibitor of the enzyme monoamine oxidase B (MAO-B). It binds to the active site of the enzyme, which prevents it from catalyzing the oxidation of monoamine neurotransmitters, such as dopamine and serotonin. This leads to an increase in the levels of these neurotransmitters. Studies have found anxiolytic, anti-inflammatory, antioxidant, antidepressant, and neuroprotective effects of MAZ51. In addition, it can improve cognitive and mitochondrial functions.
MAZ51 (CAS 163655-37-6) References
- Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. | Kirkin, V., et al. 2001. Eur J Biochem. 268: 5530-40. PMID: 11683876
- MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo. | Kirkin, V., et al. 2004. Int J Cancer. 112: 986-93. PMID: 15386354
- VEGF-C promotes survival in podocytes. | Foster, RR., et al. 2006. Am J Physiol Renal Physiol. 291: F196-207. PMID: 16525158
- VEGF-C alters barrier function of cultured lymphatic endothelial cells through a VEGFR-3-dependent mechanism. | Breslin, JW., et al. 2007. Lymphat Res Biol. 5: 105-13. PMID: 17935478
- Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles. | Ny, A., et al. 2008. Blood. 112: 1740-9. PMID: 18474726
- A VEGFR-3 antagonist increases IFN-γ expression on low functioning NK cells in acute myeloid leukemia. | Lee, JY., et al. 2013. J Clin Immunol. 33: 826-37. PMID: 23404187
- The indolinone MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells without the inhibition of VEGFR-3 phosphorylation: involvement of the RhoA and Akt/GSK3β signaling pathways. | Park, JH., et al. 2014. PLoS One. 9: e109055. PMID: 25268128
- Blockade of FLT4 suppresses metastasis of melanoma cells by impaired lymphatic vessels. | Lee, JY., et al. 2016. Biochem Biophys Res Commun. 478: 733-8. PMID: 27507214
- VEGF-C/VEGFR-3/iNOS Signaling in Osteosarcoma MG63 Cells Mediates Stimulatory Effects on Human Umbilical Vein Endothelial Cell Proliferation. | Lv, J., et al. 2021. Chin Med Sci J. 36: 35-42. PMID: 33853707
- MAZ51 Blocks the Tumor Growth of Prostate Cancer by Inhibiting Vascular Endothelial Growth Factor Receptor 3. | Yamamura, A., et al. 2021. Front Pharmacol. 12: 667474. PMID: 33959030
- VEGFR3 tyrosine kinase inhibition aggravates cisplatin nephrotoxicity. | Black, LM., et al. 2021. Am J Physiol Renal Physiol. 321: F675-F688. PMID: 34658261
- Kuoxin Decoction promotes lymphangiogenesis in zebrafish and in vitro based on network analysis. | Peng, L., et al. 2022. Front Pharmacol. 13: 915161. PMID: 36105188
- PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation. | Chang, TM., et al. 2022. J Biomed Sci. 29: 92. PMID: 36336681
- Therapeutic potential of FLT4-targeting peptide in acute myeloid leukemia. | Lee, JY., et al. 2023. Cancer Immunol Immunother.. PMID: 36763100
- Tumor Necrosis Factor-α Promotes the Tumorigenesis, Lymphangiogenesis, and Lymphatic Metastasis in Cervical Cancer via Activating VEGFC-Mediated AKT and ERK Pathways. | Chen, X., et al. 2023. Mediators Inflamm. 2023: 5679966. PMID: 37124061
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAZ51, 2 mg | sc-202703 | 2 mg | $110.00 |