Mast Cell Protease 7 Antibody (CC40): sc-80533

Mast Cell Protease 7 Antibody (CC40) is a rat monoclonal IgG2a antibody that detects Mast Cell Protease 7 of mouse origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Mast Cell Protease 7 antibody (CC40) is available as a non-conjugated format. Mast Cell Protease 7, also known as Tryptase alpha/beta 1 or MMCP-7, is predominantly expressed in differentiated mast cells and plays a crucial role in the immune response. Mast Cell Protease 7 is primarily located in the secretory granules of mast cells, which are specialized cells involved in inflammatory processes. Mast Cell Protease 7′s localization within these granules enables rapid release of proteolytic enzymes during immune responses, facilitating extracellular matrix component degradation and modulating immune cell activity. Mast Cell Protease 7 degrades fibrinogen at the endothelium/blood barrier, which may influence fibrin-platelet clot formation, thereby playing a role in hemostasis and inflammation. Factors such as Activin A, TGFβ, and Smad3 regulate Mast Cell Protease 7 gene transcription, highlighting Mast Cell Protease 7′s importance in various physiological and pathological processes.

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Mast Cell Protease 7 Antibody (CC40) References:

1. Inhibitory effect of the transcription factor encoded by the mutant mi microphthalmia allele on transactivation of mouse mast cell protease 7 gene.  |  Ogihara, H., et al. 2001. Blood. 97: 645-51. PMID: 11157480
2. Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells.  |  Gu, Y., et al. 2002. Mol Cell Biol. 22: 7645-57. PMID: 12370311
3. Transcriptional activation of mouse mast cell Protease-7 by activin and transforming growth factor-beta is inhibited by microphthalmia-associated transcription factor.  |  Funaba, M., et al. 2003. J Biol Chem. 278: 52032-41. PMID: 14527958
4. Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7.  |  McNeil, HP., et al. 1992. Proc Natl Acad Sci U S A. 89: 11174-8. PMID: 1454796
5. Transcriptional regulation of mouse mast cell protease-7 by TGF-beta.  |  Funaba, M., et al. 2006. Biochim Biophys Acta. 1759: 166-70. PMID: 16730810
6. The expression pattern of three mast cell specific proteases during mouse development.  |  Abraham, D., et al. 2007. Mol Immunol. 44: 732-40. PMID: 16777228
7. Packaging of proteases and proteoglycans in the granules of mast cells and other hematopoietic cells. A cluster of histidines on mouse mast cell protease 7 regulates its binding to heparin serglycin proteoglycans.  |  Matsumoto, R., et al. 1995. J Biol Chem. 270: 19524-31. PMID: 7642636
8. Lack of expression of the tryptase mouse mast cell protease 7 in mast cells of the C57BL/6J mouse.  |  Ghildyal, N., et al. 1994. J Immunol. 153: 2624-30. PMID: 8077672
9. The tryptase, mouse mast cell protease 7, exhibits anticoagulant activity in vivo and in vitro due to its ability to degrade fibrinogen in the presence of the diverse array of protease inhibitors in plasma.  |  Huang, C., et al. 1997. J Biol Chem. 272: 31885-93. PMID: 9395536

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mast Cell Protease 7 Antibody (CC40) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Mast Cell Protease 7 Antibody (CC40) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mast Cell Protease 7 Antibody (CC40) Specifications

Alternate Product Name: Mast Cell Protease 7

Product Clone Name: CC40

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: Mast Cell Protease 7

Epitope Species: mouse

Product Reactivity/Detection: Mast Cell Protease 7

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Mast Cell Protease 7 Antibody (CC40): N/A