Molecular structure of Mas7
Mas7 (CAS 145854-59-7)
Alternate Names:
Mastoparan 7
Application:
Mas7 is a Gαi1 and Gαoactivator
CAS Number:
145854-59-7
Purity:
≥95%
Molecular Weight:
1421.81
Molecular Formula:
C67H124N18O15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mas7 is a synthetic peptide derived from the sequence of the Mas oncogene protein, which is involved in the angiotensin receptor signaling pathway. The Mas oncogene encodes for a receptor that is part of the protective arm of the renin-angiotensin system (RAS), acting counter to the classical effects mediated by the angiotensin II type 1 receptor (AT1R). The synthetic peptide Mas7 is designed to mimic the action of the naturally occurring Mas receptor ligand, angiotensin-(1-7), and has been used extensively in research to investigate the physiological and pathological roles of the Mas receptor.
Mas7 (CAS 145854-59-7) References
- Negative regulation of the platelet Na+/H+ exchanger by trimeric G-proteins. | van Willigen, G., et al. 2000. Eur J Biochem. 267: 7102-8. PMID: 11106421
- G(alpha)(i3) in pancreatic zymogen granules participates in vesicular fusion. | Sattar, AA., et al. 2002. J Biochem. 131: 815-20. PMID: 12038977
- Pharmacological evidence that multiple phospholipid signaling pathways link Rhizobium nodulation factor perception in Medicago truncatula root hairs to intracellular responses, including Ca2+ spiking and specific ENOD gene expression. | Charron, D., et al. 2004. Plant Physiol. 136: 3582-93. PMID: 15489277
- Novel features of amphiphilic peptide Mas7 in signalling via heterotrimeric G-proteins. | Bavec, A. 2004. J Pept Sci. 10: 691-9. PMID: 15568683
- Rabbit erythrocytes possess adenylyl cyclase type II that is activated by the heterotrimeric G proteins Gs and Gi. | Sprague, R., et al. 2005. Pharmacol Rep. 57 Suppl: 222-8. PMID: 16415502
- Secretory vesicle swelling by atomic force microscopy. | Cho, SJ. and Jena, BP. 2006. Methods Mol Biol. 319: 317-30. PMID: 16719363
- Mastoparan activates calcium spiking analogous to Nod factor-induced responses in Medicago truncatula root hair cells. | Sun, J., et al. 2007. Plant Physiol. 144: 695-702. PMID: 17322338
- Receptor-mediated uptake of ferritin-bound iron by human intestinal Caco-2 cells. | Kalgaonkar, S. and Lönnerdal, B. 2009. J Nutr Biochem. 20: 304-11. PMID: 18602806
- Mastoparan-7 rescues botulinum toxin-A poisoned neurons in a mouse spinal cord cell culture model. | Zhang, P., et al. 2013. Toxicon. 76: 37-43. PMID: 24047963
- Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ. | Surve, CR., et al. 2016. Sci Signal. 9: ra22. PMID: 26905427
- Mastoparan-stimulated prolactin secretion in rat pituitary GH3 cells involves activation of Gq/11 proteins. | Yajima, Y., et al. 1997. Endocrinology. 138: 1949-58. PMID: 9112392
- Heterotrimeric G proteins are implicated in gibberellin induction of a-amylase gene expression in wild oat aleurone. | Jones, HD., et al. 1998. Plant Cell. 10: 245-54. PMID: 9490747
- Rhizobium nod factor signaling. Evidence for a g protein-mediated transduction mechanism. | Pingret, JL., et al. 1998. Plant Cell. 10: 659-72. PMID: 9596628
Activator of:
G α i1, and G α o.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mas7, 1 mg | sc-396179 | 1 mg | $180.00 |