Martinomycin (CAS 160791-16-2)

Martinomycin is a tetraene macrolide isolated from the bacterium Streptomyces martinensis. Its interest in the scientific community extends beyond its initial classification, focusing on its unique chemical structure and biosynthesis for applications in organic chemistry and biochemistry. The structure of martinomycin is highlighted by a large macrolide lactone ring and multiple conjugated double bonds (tetraene unit), which endow it with distinctive photophysical and chemical properties. Research often explores its interaction with lipids, particularly in microbial membranes. These studies are essential for understanding cell membrane integrity and function at a molecular level. Additionally, martinomycin is utilized to study the biosynthesis of complex macrolides. Investigations into the enzymatic pathways that construct its complex structure, especially the role of polyketide synthases, are vital for understanding the genetic and enzymatic mechanisms used in natural molecule assembly. This insight is invaluable for synthetic biology and the development of novel synthesis strategies.