MARCO Antibody (IBL-12): sc-65353

MARCO Antibody (IBL-12) is a rat monoclonal IgG antibody that detects mouse MARCO by immunofluorescence (IF) and flow cytometry (FCM). Anti-MARCO antibody (IBL-12) is available in non-conjugated form. The macrophage receptor with collagenous structure (MARCO) plays a crucial role in the immune response, particularly in macrophage function, providing nonspecific defense against pathogens. MARCO is primarily located on macrophage surfaces, acting as a major receptor for binding both Gram-positive and Gram-negative bacteria, facilitating their clearance from the body. MARCO (IBL-12) antibody targets a receptor especially important in alveolar macrophages, helping maintain lung health by preventing bacterial infections. MARCO is involved in silica uptake, which can lead to cytotoxic effects in murine macrophages. Mutations in MARCO genes can result in increased pulmonary inflammation and cytokine release, highlighting MARCO′s significance in maintaining immune homeostasis and pathogen clearance from lungs. MARCO′s interaction with various pathogens underscores its importance in the innate immune system, making anti-MARCO antibody (IBL-12) valuable for studying macrophage function and immune responses in mouse models.

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MARCO Antibody (IBL-12) References:

1. Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.  |  La Fleur, L., et al. 2021. Cancer Res. 81: 956-967. PMID: 33293426
2. Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.  |  Chen, AX., et al. 2021. Genome Med. 13: 88. PMID: 34011400
3. TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.  |  Wang, L., et al. 2021. Mol Neurobiol. 58: 5743-5755. PMID: 34398403
4. MARCO is a potential prognostic and immunotherapy biomarker.  |  Dong, Q., et al. 2023. Int Immunopharmacol. 116: 109783. PMID: 36773567
5. UGRP1-modulated MARCO+ alveolar macrophages contribute to age-related lung fibrosis.  |  Chen, Y., et al. 2023. Immun Ageing. 20: 14. PMID: 36934284
6. MARCO Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection through Intensifying Viral GP5-Induced Apoptosis.  |  Zhang, X., et al. 2023. Microbiol Spectr. 11: e0475322. PMID: 37078873
7. Long-Chain Acyl Carnitines Aggravate Polystyrene Nanoplastics-Induced Atherosclerosis by Upregulating MARCO.  |  Wang, B., et al. 2023. Adv Sci (Weinh). 10: e2205876. PMID: 37144527
8. Blocking MARCO+ tumor-associated macrophages improves anti-PD-L1 therapy of hepatocellular carcinoma by promoting the activation of STING-IFN type I pathway.  |  Ding, L., et al. 2024. Cancer Lett. 582: 216568. PMID: 38065400
9. The application of MARCO for immune regulation and treatment.  |  Zhou, G., et al. 2024. Mol Biol Rep. 51: 246. PMID: 38300385
10. The co-location of MARCO+ tumor-associated macrophages and CTSE+ tumor cells determined the poor prognosis in intrahepatic cholangiocarcinoma.  |  Fan, G., et al. 2024. Hepatology.. PMID: 39471066

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MARCO Antibody (IBL-12) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MARCO Antibody (IBL-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MARCO Antibody (IBL-12) Specifications

Alternate Product Name: MARCO

Product Clone Name: IBL-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids:

Epitope Target: MARCO

Epitope Species: mouse

Product Reactivity/Detection: MARCO

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 100 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MARCO Antibody (IBL-12): N/A

The preferred MARCO antibody is MARCO Antibody (F-3): sc-398053.