MARCH4 Antibody (A-1): sc-514837

MARCH4 Antibody (A-1) is a mouse monoclonal IgM antibody that detects MARCH4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MARCH4 antibody (A-1) is available as the non-conjugated format. MARCH4, also known as RNF174, is a 410 amino acid multi-pass membrane protein that plays a crucial role in ubiquitination, which is essential for regulating protein degradation within cells. MARCH4 is primarily localized to the Golgi apparatus, where MARCH4 functions as an E3 ubiquitin-protein ligase, facilitating ubiquitin transfer from ubiquitin-conjugating enzymes to target proteins, such as CD4 and MHC-I. MARCH4′s ability to promote degradation of these proteins is vital for maintaining immune system homeostasis and preventing autoimmune responses. The gene encoding MARCH4 is located on human chromosome 2, a region containing over 1,400 genes and representing nearly 8% of the human genome, highlighting MARCH4′s importance in various biological processes.

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MARCH4 Antibody (A-1) References:

1. A gene expression atlas of the central nervous system based on bacterial artificial chromosomes.  |  Gong, S., et al. 2003. Nature. 425: 917-25. PMID: 14586460
2. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.  |  Bartee, E., et al. 2004. J Virol. 78: 1109-20. PMID: 14722266
3. Ubiquitin, proteasomes, and the regulation of intracellular protein degradation.  |  Hochstrasser, M. 1995. Curr Opin Cell Biol. 7: 215-23. PMID: 7612274
4. The ubiquitin-proteasome proteolytic pathway.  |  Ciechanover, A. 1994. Cell. 79: 13-21. PMID: 7923371
5. The ubiquitin-mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins.  |  Ciechanover, A. and Schwartz, AL. 1994. FASEB J. 8: 182-91. PMID: 8119489
6. A novel protein modification pathway related to the ubiquitin system.  |  Liakopoulos, D., et al. 1998. EMBO J. 17: 2208-14. PMID: 9545234

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MARCH4 Antibody (A-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MARCH4 Antibody (A-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MARCH4 Antibody (A-1) Specifications

Alternate Product Name: MARCH4

Product Clone Name: A-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 354-371

Epitope Target: MARCH4

Epitope Species: mouse

Product Reactivity/Detection: MARCH4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MARCH4 Antibody (A-1): P: Blocking Peptide