Marburg Virus Antibody (FM11): sc-52066

Marburg Virus Antibody (FM11) is a mouse monoclonal IgG1 antibody that detects the Marburg Virus protein of Marburg Virus origin by western blotting (WB) under non-reducing conditions, as well as a ~30K protein band under reducing conditions. Marburg Virus (FM11) antibody is available in a non-conjugated form, providing researchers with a reliable tool for studying this highly pathogenic virus. Marburg Virus, a member of the Filoviridae family, is notorious for causing Marburg hemorrhagic fever, a severe and often fatal disease characterized by high fever, vomiting, diarrhea, and extensive bleeding. The virus is composed of long, threadlike particles that can range from 800 nm to 14,000 nm in length, which is crucial for infectivity and ability to evade the host immune response. Understanding the structure of Marburg Virus is vital, as this knowledge informs the development of therapeutic strategies and vaccines. The unique filamentous morphology allows efficient host cell entry and replication, leading to severe symptoms associated with the disease. Given the high mortality rate and potential for outbreaks, studying Marburg Virus and host cell interactions remains paramount in virology and public health.

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Marburg Virus Antibody (FM11) References:

1. Adverse effects of MVA-T7 on the transport of Marburg virus glycoprotein.  |  Sänger, C., et al. 2001. J Virol Methods. 91: 29-35. PMID: 11164483
2. [Detection of antiviral activity of monoclonal antibodies, specific to Marburg virus proteins].  |  Razumov, IA., et al. 2001. Vopr Virusol. 46: 33-7. PMID: 11233285
3. The Marburg virus surface protein GP is phosphorylated at its ectodomain.  |  Sänger, C., et al. 2002. Virology. 295: 20-9. PMID: 12033762
4. Mapping of two dominant sites of VP35 of Marburg virus.  |  Sorokin, AV., et al. 2002. Viral Immunol. 15: 481-92. PMID: 12479397
5. [Ebola virus and Marburg virus].  |  Morikawa, S. 2003. Nihon Rinsho. 61 Suppl 3: 544-9. PMID: 12718026
6. Characterization of monoclonal antibodies to Marburg virus (strain Musoke) glycoprotein and identification of two protective epitopes.  |  Hevey, M., et al. 2003. Virology. 314: 350-7. PMID: 14517087
7. The matrix protein of Marburg virus is transported to the plasma membrane along cellular membranes: exploiting the retrograde late endosomal pathway.  |  Kolesnikova, L., et al. 2004. J Virol. 78: 2382-93. PMID: 14963134
8. VP24 of Marburg virus influences formation of infectious particles.  |  Bamberg, S., et al. 2005. J Virol. 79: 13421-33. PMID: 16227263
9. Geographic potential for outbreaks of Marburg hemorrhagic fever.  |  Peterson, AT., et al. 2006. Am J Trop Med Hyg. 75: 9-15. PMID: 16837700
10. Vaccines against Ebola virus and Marburg virus: recent advances and promising candidates.  |  Suschak, JJ. and Schmaljohn, CS. 2019. Hum Vaccin Immunother. 15: 2359-2377. PMID: 31589088
11. Marburg virus pathogenesis - differences and similarities in humans and animal models.  |  Shifflett, K. and Marzi, A. 2019. Virol J. 16: 165. PMID: 31888676
12. Systematic review of Marburg virus vaccine nonhuman primate studies and human clinical trials.  |  Dulin, N., et al. 2021. Vaccine. 39: 202-208. PMID: 33309082

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Marburg Virus Antibody (FM11) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Marburg Virus Antibody (FM11) Specifications

Alternate Product Name: Marburg Virus

Product Clone Name: FM11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Marburg Virus

Epitope Species: Marburg Virus

Product Reactivity/Detection: high molecular weight material under non-reducing conditions and ~30K protein band under reducing conditions

Species Reactivity/Detection: Marburg Virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: Marburg Virus

Applications: WB (non-reducing)

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Marburg Virus Antibody (FM11): N/A