Date published: 2026-2-27

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Marbofloxacin-d8 (CAS 1185053-37-5)

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Alternate Names:
9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl-d8)-7-oxo-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazine-6-carboxylic Acid
CAS Number:
1185053-37-5
Molecular Weight:
370.40
Molecular Formula:
C17H11D8FN4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Marbofloxacin-d8′s mechanism of action involves inhibiting the bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for DNA replication, transcription, and repair. By binding to these enzymes, marbofloxacin-d8 disrupts the normal cellular processes of bacteria, ultimately leading to the inhibition of bacterial growth and reproduction. Marbofloxacin-d8 interacts with the ATP-binding site of DNA gyrase and topoisomerase IV, preventing the enzymes from carrying out their functions. This interference with the enzymes′ activities results in the accumulation of double-stranded DNA breaks and the formation of abnormal DNA structures within the bacterial cells. As a consequence, the bacteria are unable to proliferate and are susceptible to the immune system or other antimicrobial agents. Marbofloxacin-d8 exerts its antibacterial effects by targeting and disrupting cellular enzymes involved in DNA metabolism, ultimately leading to the inhibition of bacterial replication and survival.


Marbofloxacin-d8 (CAS 1185053-37-5) References

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  2. Pharmacokinetics of enrofloxacin and marbofloxacin in Japanese quails and common pheasants.  |  Lashev, LD., et al. 2015. Br Poult Sci. 56: 255-61. PMID: 25567298
  3. Marbofloxacin-encapsulated microparticles provide sustained drug release for treatment of veterinary diseases.  |  Lee, J., et al. 2016. Mater Sci Eng C Mater Biol Appl. 60: 511-517. PMID: 26706558
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  5. Pharmacokinetic-pharmacodynamic integration of marbofloxacin after single and repeated intravenous administration in goats.  |  Bhardwaj, P., et al. 2018. Res Vet Sci. 121: 111-115. PMID: 30384141
  6. Distribution of marbofloxacin in the bronchoalveolar region in healthy calves.  |  Hayashi, J., et al. 2019. J Vet Med Sci. 81: 730-733. PMID: 30918227
  7. The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs.  |  Altan, F., et al. 2019. Trop Anim Health Prod. 51: 2603-2610. PMID: 31230255
  8. Rapid determination of marbofloxacin by surface-enhanced Raman spectroscopy of silver nanoparticles modified by β-cyclodextrin.  |  Zhao, R., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 229: 118009. PMID: 31927237
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Marbofloxacin-d8, 500 µg

sc-218672
500 µg
$450.00

Marbofloxacin-d8, 1 mg

sc-218672-CW
1 mg
$900.00