Molecular structure of Maprotiline Hydrochloride, CAS Number: 10347-81-6
Maprotiline Hydrochloride (CAS 10347-81-6)
See product citations (7)
Alternate Names:
Ludiomil; Psymion
Application:
Maprotiline Hydrochloride is A norepinephrine reuptake inhibitor shown to block apoptosis of spiny neurons
CAS Number:
10347-81-6
Purity:
≥98%
Molecular Weight:
313.87
Molecular Formula:
C20H23N•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Maprotiline Hydrochloride is derived from the alkaloid lysergic acid. This synthetic compound shares structural similarities with other TCAs like amitriptyline and imipramine. Extensive investigations involving both in vivo and in vitro experiments have been conducted to elucidate Maprotiline Hydrochloride′s mechanism of action, biological activity, biochemical and physiological effects, as well as the advantages and limitations of its application in laboratory applications. The precise mechanism of action of Maprotiline Hydrochloride is not yet fully comprehended. However, it is believed to function as a serotonin and norepinephrine reuptake inhibitor, consequently elevating the levels of these neurotransmitters in the brain.
Maprotiline Hydrochloride (CAS 10347-81-6) References
- Determination of norepinephrine in microdialysis samples by microbore column liquid chromatography with fluorescence detection following derivatization with benzylamine. | Yamaguchi, M., et al. 1999. Anal Biochem. 270: 296-302. PMID: 10334847
- Serotonin and noradrenaline reuptake inhibitors in animal models of pain. | Mochizucki, D. 2004. Hum Psychopharmacol. 19 Suppl 1: S15-9. PMID: 15378668
- Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease. | Tang, TS., et al. 2005. Proc Natl Acad Sci U S A. 102: 2602-7. PMID: 15695335
- Antidepressants and their effect on sleep. | Mayers, AG. and Baldwin, DS. 2005. Hum Psychopharmacol. 20: 533-59. PMID: 16229049
- [The effect of changing the association properties of psychopharmaceuticals in colloidal solutions on their liberation. 4. The effect of chemical structure as well as environmental conditions on the elevation of critical micelle formation concentration and reduction of micelle weight with hydrotropic material]. | Thoma, K. and von Stein, C. 1990. Pharm Acta Helv. 65: 98-104. PMID: 2356194
- Potentiometric Determination of Maprotiline Hydrochloride in Pharmaceutical and Biological Matrices Using a Novel Modified Carbon Paste Electrode. | Radić, J., et al. 2022. Sensors (Basel). 22: PMID: 36501902
- A preliminary report on anti-depressant therapy and its effects on hope and immunity. | Udelman, DL. and Udelman, HD. 1985. Soc Sci Med. 20: 1069-72. PMID: 3874433
- Epileptiform seizures with maprotiline hydrochloride. | Marks, P., et al. 1979. Postgrad Med J. 55: 742. PMID: 537962
- Treatment of depression with maprotiline hydrochloride: multicenter evaluation of efficacy and tolerability. | . 1983. Clin Ther. 5: 377-84. PMID: 6347381
- Multicenter evaluation of maprotiline hydrochloride for treatment of depression. | . 1984. Clin Ther. 6: 155-62. PMID: 6367987
- Maprotiline hydrochloride associated with a clinical state of catatonic stupor and epileptic encephalogram. | Atri, PB. and Julius, DA. 1984. J Clin Psychopharmacol. 4: 207-9. PMID: 6470193
- Maprotiline hydrochloride and convulsions: a case report. | Schwartz, L. and Swaminathan, S. 1982. Am J Psychiatry. 139: 244-5. PMID: 6798885
- [Effect of maprotiline hydrochloride on oxygen and glucose consumption and oxidative phosphorylation of rat brain in vitro]. | Saiz, I., et al. 1978. Arch Farmacol Toxicol. 4: 37-8. PMID: 697400
Inhibitor of:
Apoptosis, and SLC6A2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Maprotiline Hydrochloride, 1 g | sc-200156 | 1 g | $73.00 |