Molecular structure of MAP4, CAS Number: 157381-42-5
MAP4 (CAS 157381-42-5)
Alternate Names:
(S)-2-Amino-2-methyl-4-phosphonobutanoic acid
Application:
MAP4 is a selective group III mGluR (metabotropic glutamate receptor) agonist
CAS Number:
157381-42-5
Molecular Weight:
197.1
Molecular Formula:
C5H12NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
157381-42-5 is a selective agonist for group III mGluRs.
MAP4 (CAS 157381-42-5) References
- Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. | Chapman, AG., et al. 2001. Eur J Pharmacol. 424: 107-13. PMID: 11476756
- Activation of spinal metabotropic glutamate receptors elicits cardiovascular responses in pentobarbital anesthetized rats. | Celuch, SM. and García, Mdel C. 2002. Naunyn Schmiedebergs Arch Pharmacol. 366: 343-9. PMID: 12237748
- Distinct presynaptic metabotropic receptors for L-AP4 and CCG1 on GABAergic terminals: pharmacological evidence using novel alpha-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamus in vivo. | Salt, TE. and Eaton, SA. 1995. Neuroscience. 65: 5-13. PMID: 7753406
- Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord. | Jane, DE., et al. 1994. Br J Pharmacol. 112: 809-16. PMID: 7921606
- Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. | Watkins, J. and Collingridge, G. 1994. Trends Pharmacol Sci. 15: 333-42. PMID: 7992387
- Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes. | Knöpfel, T., et al. 1995. Neuropharmacology. 34: 1099-102. PMID: 8532159
- Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. | Sekiyama, N., et al. 1996. Br J Pharmacol. 117: 1493-503. PMID: 8730745
- Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. | Gomeza, J., et al. 1996. Mol Pharmacol. 50: 923-30. PMID: 8863838
- Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices. | Kemp, MC., et al. 1996. Eur J Pharmacol. 309: 79-85. PMID: 8864697
- L-AP4 (L-(+)-2-amino-4-phosphonobutyric acid) induced impairment of spatial learning in the rat is antagonized by MAP4 ((S)-2-amino-2-methyl-4-phosphonobutanoic acid). | Hölscher, C., et al. 1996. Behav Brain Res. 81: 69-79. PMID: 8950003
- Glutamate metabotropic receptor agonists depress excitatory and inhibitory transmission on rat mesencephalic principal neurons. | Bonci, A., et al. 1997. Eur J Neurosci. 9: 2359-69. PMID: 9464930
- Neuroprotective effects of group III mGluR in traumatic neuronal injury. | Faden, AI., et al. 1997. J Neurotrauma. 14: 885-95. PMID: 9475370
- Potentiation by DL-alpha-aminopimelate of the inhibitory action of a novel mGluR agonist (L-F2CCG-I) on monosynaptic excitation in the rat spinal cord. | Saitoh, T., et al. 1998. Br J Pharmacol. 123: 771-9. PMID: 9517398
Inhibitor of:
mGluR-4, mGluR-6, mGluR-7, and mGLuR-8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAP4, 5 mg | sc-202221 | 5 mg | $40.00 |