MAP-4 Antibody (18): sc-135980
- MAP-4 Antibody (18) is a mouse monoclonal IgG1 provided at 50 µg/500 µl
- raised against amino acids 583-702 of MAP-4 of human origin
- recommended for detection of MAP-4 of human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MAP-4 Antibody (18). This work is in progress.
MAP-4 Antibody (18) is a mouse monoclonal IgG1 antibody that detects MAP-4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). MAP-4 is a crucial microtubule-associated protein that plays a significant role in the assembly and stability of microtubules, which are essential components of the cytoskeletal network. Anti-MAP-4 antibody (18) influences the organization and dynamics of microtubules during various cellular processes, including cell division and intracellular transport. MAP-4 contains three 18-amino acid repeats that are homologous to those found in other microtubule-associated proteins, highlighting its structural significance. MAP-4 is primarily expressed in tissues such as the kidney, lung, liver, testis, and spleen, where MAP-4 contributes to the proper functioning of microtubules in both interphase and mitotic phases. MAP-4′s ability to enhance microtubule stability and facilitate the translocation of cellular components underscores MAP-4′s importance in maintaining cellular integrity and function, making MAP-4 monoclonal antibody (18) an invaluable tool for researchers studying microtubule dynamics and related cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MAP-4 Antibody (18) References:
- Microtubule-associated protein-4 (MAP-4) inhibits microtubule-dependent distribution of mRNA in isolated neonatal cardiocytes. | Scholz, D., et al. 2006. Cardiovasc Res. 71: 506-16. PMID: 16750521
- Effect of microtubule-associated protein-4 on epidermal cell migration under different oxygen concentrations. | Chen, X., et al. 2016. J Dermatol. 43: 674-81. PMID: 26602869
- Microtubule-associated protein-4 controls nanovesicle dynamics and T cell activation. | Bustos-Morán, E., et al. 2017. J Cell Sci. 130: 1217-1223. PMID: 28209780
- Microtubule associated protein 4 phosphorylation leads to pathological cardiac remodeling in mice. | Li, L., et al. 2018. EBioMedicine. 37: 221-235. PMID: 30327268
- Microtubule-associated protein 4 phosphorylation regulates epidermal keratinocyte migration and proliferation. | Zhang, J., et al. 2019. Int J Biol Sci. 15: 1962-1976. PMID: 31523197
- Microtubule associated protein 4 (MAP4) phosphorylation reduces cardiac microvascular density through NLRP3-related pyroptosis. | Feng, YH., et al. 2021. Cell Death Discov. 7: 213. PMID: 34381021
- Microtubule associated protein 4 phosphorylation-induced epithelial-to-mesenchymal transition of podocyte leads to proteinuria in diabetic nephropathy. | Li, L., et al. 2022. Cell Commun Signal. 20: 115. PMID: 35902952
- The ubiquitous microtubule-associated protein 4 (MAP4) controls organelle distribution by regulating the activity of the kinesin motor. | Nabti, I., et al. 2022. Proc Natl Acad Sci U S A. 119: e2206677119. PMID: 36191197
- Microtubule-associated protein 4 promotes epithelial mesenchymal transition in hepatocellular cancer cells via regulating GSK3β/β-catenin pathway. | Hu, P., et al. 2023. Heliyon. 9: e14309. PMID: 36938447
- The Roles of Microtubule-Associated Protein 4 in Wound Healing and Human Diseases. | Chen, Q., et al. 2023. Front Biosci (Landmark Ed). 28: 76. PMID: 37114541
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAP-4 Antibody (18) | sc-135980 | 50 µg/500 µl | $322.00 |