Date published: 2025-11-22

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Manzamine A (CAS 104196-68-1)

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Alternate Names:
Keramamine A
Application:
Manzamine A is a β-Carboline alkaloid with anti-inflammatory
CAS Number:
104196-68-1
Purity:
>98%
Molecular Weight:
548.76
Molecular Formula:
C36H44N4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Manzamine A is a compound that has interest in the field of natural products chemistry. Its complex macrocyclic structure provides a valuable framework for studying the chemical ecology of marine organisms, particularly sponges. Researchers are focused on the biosynthesis of Manzamine A, aiming to unravel the genetic and enzymatic pathways that lead to its production in nature. This compound also serves as a scaffold in synthetic chemistry for the generation of novel compounds that can be used to investigate various biological pathways. Manzamine A is further studied for its role in the chemical defense mechanisms of marine organisms, offering insights into the evolutionary pressures that shape these compounds. Additionally, in the field of materials science, the unique structural features of Manzamine A are explored for the design of new compounds with potential applications in the development of functional materials. Researchers also use Manzamine A to study its interaction with other marine compounds, which can reveal synergistic or antagonistic effects within the marine chemical milieu.


Manzamine A (CAS 104196-68-1) References

  1. In vivo antimalarial activity of the beta-carboline alkaloid manzamine A.  |  Ang, KK., et al. 2000. Antimicrob Agents Chemother. 44: 1645-9. PMID: 10817722
  2. Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A.  |  Ang, KK., et al. 2001. Parasitol Res. 87: 715-21. PMID: 11570556
  3. New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge.  |  Rao, KV., et al. 2003. J Nat Prod. 66: 823-8. PMID: 12828469
  4. Spectrofluorimetric determination of manzamine A in spiked human urine and plasma.  |  Khalil, A., et al. 2003. Pharmazie. 58: 385-8. PMID: 12856999
  5. New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases.  |  Yousaf, M., et al. 2004. J Med Chem. 47: 3512-7. PMID: 15214779
  6. Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.  |  Hamann, M., et al. 2007. J Nat Prod. 70: 1397-405. PMID: 17708655
  7. Manzamine A as a novel inhibitor of herpes simplex virus type-1 replication in cultured corneal cells.  |  Palem, JR., et al. 2011. Planta Med. 77: 46-51. PMID: 20645244
  8. Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo.  |  Eguchi, K., et al. 2013. Bioorg Med Chem. 21: 3831-8. PMID: 23665143
  9. The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells.  |  Kallifatidis, G., et al. 2013. Mar Drugs. 11: 3500-16. PMID: 24048269
  10. Manzamine A Exerts Anticancer Activity against Human Colorectal Cancer Cells.  |  Lin, LC., et al. 2018. Mar Drugs. 16: PMID: 30060617
  11. The Marine Natural Product Manzamine A Inhibits Cervical Cancer by Targeting the SIX1 Protein.  |  Karan, D., et al. 2020. J Nat Prod. 83: 286-295. PMID: 32022559
  12. Manzamine-A Alters In Vitro Calvarial Osteoblast Function.  |  Hardy, S., et al. 2022. Mar Drugs. 20: PMID: 36286470
  13. Four new bioactive manzamine-type alkaloids from the Philippine marine sponge Xestospongia ashmorica.  |  Edrada, RA., et al. 1996. J Nat Prod. 59: 1056-60. PMID: 8946747

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Manzamine A, 1 mg

sc-202220
1 mg
$275.00