Date published: 2026-4-29

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Malformin C (CAS 59926-78-2)

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Alternate Names:
(−)-cyclo[D-Cys(1)-D-Cys(1)-L-Val-D-Leu-L-Leu-]
Application:
Malformin C is an inhibitor of bleomycin-induced G2 arrest
CAS Number:
59926-78-2
Molecular Weight:
529.72
Molecular Formula:
C23H39N5O5S2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Malformin C is a mycotoxin found in certain strains of the fungus Aspergillus niger and is recognized for its potential in agricultural and biological research. It has been studied for its unique phytotoxic effects, such as inducing malformations in plants, which makes it a tool for understanding plant growth and development pathways. The compound′s ability to interfere with normal plant hormone signaling can provide insights into the regulation of plant morphology. Additionally, Malformin C is used in cellular studies to examine its influence on cell proliferation and cytoskeleton dynamics due to its actin polymerization properties. Research involving Malformin C also extends to probing its biosynthetic pathways, which are of interest for discovering novel bioactive molecules and understanding fungal secondary metabolite production.


Malformin C (CAS 59926-78-2) References

  1. Biosynthetically diverse compounds from a saltwater culture of sponge-derived Aspergillus niger.  |  Varoglu, M. and Crews, P. 2000. J Nat Prod. 63: 41-3. PMID: 10650076
  2. Malformin C, a new metabolite of Aspergillus niger.  |  Anderegg, RJ., et al. 1976. J Am Chem Soc. 98: 3365-70. PMID: 1262650
  3. Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells.  |  Hagimori, K., et al. 2007. Biol Pharm Bull. 30: 1379-83. PMID: 17666789
  4. Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest.  |  Kojima, Y., et al. 2008. J Antibiot (Tokyo). 61: 297-302. PMID: 18653995
  5. Solid-phase synthesis and biological activity of malformin C and its derivatives.  |  Kojima, Y., et al. 2009. J Antibiot (Tokyo). 62: 681-6. PMID: 19876076
  6. Proteome analysis of Aspergillus niger: lactate added in starch-containing medium can increase production of the mycotoxin fumonisin B2 by modifying acetyl-CoA metabolism.  |  Sørensen, LM., et al. 2009. BMC Microbiol. 9: 255. PMID: 20003296
  7. Study of Malformin C, a Fungal Source Cyclic Pentapeptide, as an Anti-Cancer Drug.  |  Wang, J., et al. 2015. PLoS One. 10: e0140069. PMID: 26540166
  8. New cytotoxic furan from the marine sediment-derived fungi Aspergillus niger.  |  Uchoa, PKS., et al. 2017. Nat Prod Res. 31: 2599-2603. PMID: 28135874
  9. Mycobacterium smegmatis alters the production of secondary metabolites by marine-derived Aspergillus niger.  |  Jomori, T., et al. 2020. J Nat Med. 74: 76-82. PMID: 31321600
  10. Calm Before the Storm: A Glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the Etiologic Agent of the Sisal Bole Rot.  |  Quintanilha-Peixoto, G., et al. 2019. Toxins (Basel). 11: PMID: 31671681
  11. Diversity and toxigenicity of fungi and description of Fusarium madaense sp. nov. from cereals, legumes and soils in north-central Nigeria.  |  Ezekiel, CN., et al. 2020. MycoKeys. 67: 95-124. PMID: 32565683
  12. Malformin C, an algicidal peptide from marine fungus Aspergillus species.  |  Li, X., et al. 2021. Ecotoxicology. 30: 996-1003. PMID: 33755843
  13. Production and antibacterial activity of malforming C, a toxic metabolite of Aspergillus niger.  |  Kobbe, B., et al. 1977. Appl Environ Microbiol. 33: 996-7. PMID: 869543

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Malformin C, 250 µg

sc-280953
250 µg
$119.00

Malformin C, 1 mg

sc-280953A
1 mg
$349.00