Date published: 2026-5-20

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MAHMA NONOate (CAS 146724-86-9)

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Alternate Names:
NOC-9
Application:
MAHMA NONOate is a diazeniumdiolate quick-releasing NO donor
CAS Number:
146724-86-9
Purity:
≥98%
Molecular Weight:
204.27
Molecular Formula:
C8H20N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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MAHMA NONOate is a compound used in research to release nitric oxide (NO) in a controlled manner. As a donor of nitric oxide, MAHMA NONOate is utilized in studies to understand the role of NO as a signaling molecule in various biological systems. Nitric oxide is involved in the regulation of many physiological processes, making this compound useful in physiological and pathophysiological research. Its controlled release properties allow for the investigation of NO-related mechanisms in real-time, aiding in the study of cardiovascular function, neural activity, and the body′s defense mechanisms. Additionally, MAHMA NONOate is used in the analysis of the molecular targets of nitric oxide and the downstream effects of its interaction with other biomolecules.


MAHMA NONOate (CAS 146724-86-9) References

  1. Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate.  |  Homer, KL. and Wanstall, JC. 2002. Br J Pharmacol. 137: 1071-81. PMID: 12429580
  2. Platelet inhibitory effects of the nitric oxide donor drug MAHMA NONOate in vivo in rats.  |  Homer, KL. and Wanstall, JC. 2003. Eur J Pharmacol. 482: 265-70. PMID: 14660031
  3. Specific inhibitory effects of the NO donor MAHMA/NONOate on human platelets.  |  Kobsar, A., et al. 2014. Eur J Pharmacol. 735: 169-76. PMID: 24780647
  4. Exploitation of nitric oxide donors to control bacterial adhesion on ready-to-eat vegetables and dispersal of pathogenic biofilm from polypropylene.  |  Islam, M., et al. 2020. J Sci Food Agric. 100: 3078-3086. PMID: 32077490
  5. Recent Developments in Pharmacological Effect, Mechanism and Application Prospect of Diazeniumdiolates.  |  Li, B., et al. 2020. Front Pharmacol. 11: 923. PMID: 32655397
  6. Optimization of nitric oxide donors for investigating biofilm dispersal response in Pseudomonas aeruginosa clinical isolates.  |  Cai, YM. and Webb, JS. 2020. Appl Microbiol Biotechnol. 104: 8859-8869. PMID: 32865612
  7. Genetic engineering of circularly permuted yellow fluorescent protein reveals intracellular acidification in response to nitric oxide stimuli.  |  Deng, H., et al. 2021. Redox Biol. 41: 101943. PMID: 33752109
  8. Characterization of endothelium-dependent and -independent processes in occipital artery of the rat: relevance to control of blood flow to nodose sensory cells.  |  Lewis, THJ., et al. 2021. J Appl Physiol (1985). 131: 1067-1079. PMID: 34323595
  9. Microbial disruption in the gut promotes cerebral endothelial dysfunction.  |  Rustia, AJ., et al. 2021. Physiol Rep. 9: e15100. PMID: 34755466
  10. Recent Developments in Nitric Oxide Donors and Delivery for Antimicrobial and Anti-Biofilm Applications.  |  Poh, WH. and Rice, SA. 2022. Molecules. 27: PMID: 35163933
  11. Inhibition of Cu2+-induced LDL oxidation by nitric oxide: a study using donors with different half-time of NO release.  |  Seccia, M., et al. 1996. Biochem Biophys Res Commun. 220: 306-9. PMID: 8645301
  12. 'NONOates' (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms.  |  Keefer, LK., et al. 1996. Methods Enzymol. 268: 281-93. PMID: 8782594
  13. Nitric oxide protects the skeletal muscle Ca2+ release channel from oxidation induced activation.  |  Aghdasi, B., et al. 1997. J Biol Chem. 272: 25462-7. PMID: 9325258

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

MAHMA NONOate, 10 mg

sc-202250
10 mg
$52.00