MAGE-A11 Antibody (YN-2): sc-101222

MAGE-A11 Antibody (YN-2) is a mouse monoclonal IgM antibody that detects MAGE-A11 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-MAGE-A11 antibody (YN-2) is available as the non-conjugated monoclonal isotype antibody. The melanoma-associated antigen (MAGE) family, which includes MAGE-A11, is crucial in cancer immunotherapy due to tumor-specific expression patterns. MAGE-A11, also known as melanoma antigen family A, 11, MAGE11, MAGE-11, or CT1.11 (cancer/testis antigen 1.11), is a 429 amino acid protein predominantly localized in both nucleus and cytoplasm, containing a single MAGE domain. MAGE-A11 is expressed in various tumors, including melanoma, breast cancer, and lung cancer, and serves as a co-regulator of the androgen receptor (AR), enhancing AR activity by modulating interdomain interactions. The regulation of AR by MAGE-A11 is significant as MAGE-A11 is believed to influence embryonic development and contribute to tumor progression and transformation. Notably, MAGE-A11 exists in two isoforms due to alternative splicing, which may have implications for functional diversity and role in different cancer types.

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MAGE-A11 Antibody (YN-2) References:

1. Additional upstream coding sequences of MAGE-11.  |  Irvine, RA. and Coetzee, GA. 1999. Immunogenetics. 49: 585. PMID: 10380710
2. Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries.  |  Serrano, A., et al. 1999. Int J Cancer. 83: 664-9. PMID: 10521804
3. Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction.  |  Bai, S., et al. 2005. Mol Cell Biol. 25: 1238-57. PMID: 15684378
4. Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone.  |  Askew, EB., et al. 2007. J Biol Chem. 282: 25801-16. PMID: 17591767
5. Epidermal-growth-factor-dependent phosphorylation and ubiquitinylation of MAGE-11 regulates its interaction with the androgen receptor.  |  Bai, S. and Wilson, EM. 2008. Mol Cell Biol. 28: 1947-63. PMID: 18212060
6. Structure, chromosomal localization, and expression of 12 genes of the MAGE family.  |  De Plaen, E., et al. 1994. Immunogenetics. 40: 360-9. PMID: 7927540
7. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28.  |  Rogner, UC., et al. 1995. Genomics. 29: 725-31. PMID: 8575766
8. MAGE-11 protein is highly conserved in higher organisms and located predominantly in the nucleus.  |  Jurk, M., et al. 1998. Int J Cancer. 75: 762-6. PMID: 9495246