Magainin 1 (CAS 108433-99-4)
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Magainin 1 is a peptide originally identified in the skin of the African clawed frog and is the subject of extensive research due to its potent antimicrobial properties. It is studied for its ability to disrupt bacterial cell membranes, providing insights into alternative strategies for combating bacterial infections. Researchers also investigate Magainin 1′s mechanism of action, exploring how its amphipathic nature enables it to integrate into lipid bilayers and cause cell lysis. In addition to its antibacterial activity, Magainin 1 is examined for its antifungal and antiviral potential, making it a compound of interest in the study of innate immune defenses. Furthermore, its role in the development of new antimicrobial materials, such as coatings and hydrogels, is also a significant area of inquiry, particularly in the context of preventing biofilm formation.
Magainin 1 (CAS 108433-99-4) References
- Initial binding sites of antimicrobial peptides in Staphylococcus aureus and Escherichia coli. | Vorland, LH., et al. 1999. Scand J Infect Dis. 31: 467-73. PMID: 10576125
- Antitumor activity of magainin analogues against human lung cancer cell lines. | Ohsaki, Y., et al. 1992. Cancer Res. 52: 3534-8. PMID: 1319823
- Magainin 2, a natural antibiotic from frog skin, forms ion channels in lipid bilayer membranes. | Cruciani, RA., et al. 1992. Eur J Pharmacol. 226: 287-96. PMID: 1383011
- In vitro toxicity towards kiwifruit pollen of the antimicrobial peptides magainins 1 and 2. | Speranza, AM., et al. 2007. Plant Biol (Stuttg). 9: 800-6. PMID: 17564946
- The antibacterial activity of Magainin I immobilized onto mixed thiols Self-Assembled Monolayers. | Humblot, V., et al. 2009. Biomaterials. 30: 3503-12. PMID: 19345992
- Hybridization between the African clawed frogs Xenopus laevis and Xenopus muelleri (Pipidae) increases the multiplicity of antimicrobial peptides in skin secretions of female offspring. | Mechkarska, M., et al. 2012. Comp Biochem Physiol Part D Genomics Proteomics. 7: 285-91. PMID: 22687652
- Phosphorylation of magainin-2 by protein kinase C and inhibition of protein kinase C isozymes by a synthetic analogue of magainin-2-amide. | Nakabayashi, H., et al. 1990. FEBS Lett. 267: 135-8. PMID: 2365080
- Channel Current Analysis for Pore-forming Properties of an Antimicrobial Peptide, Magainin 1, Using the Droplet Contact Method. | Watanabe, H. and Kawano, R. 2016. Anal Sci. 32: 57-60. PMID: 26753706
- Magainin 1-induced leakage of entrapped calcein out of negatively-charged lipid vesicles. | Matsuzaki, K., et al. 1989. Biochim Biophys Acta. 981: 130-4. PMID: 2719968
- A microfluidic enrichment platform with a recombinase polymerase amplification sensor for pathogen diagnosis. | Dao, TNT., et al. 2018. Anal Biochem. 544: 87-92. PMID: 29289485
- The Magainins: sequence factors relevant to increased antimicrobial activity and decreased hemolytic activity. | Cuervo, JH., et al. 1988. Pept Res. 1: 81-6. PMID: 2980783
- Atomic force spectroscopy with magainin 1 functionalized tips and biomimetic supported lipid membranes. | Besleaga, A., et al. 2022. Eur Biophys J. 51: 29-40. PMID: 35031815
- Anurans against SARS-CoV-2: A review of the potential antiviral action of anurans cutaneous peptides. | de Amaral, M. and Ienes-Lima, J. 2022. Virus Res. 315: 198769. PMID: 35430319
- In vitro activity of the antimicrobial peptide magainin 1 against Bonamia ostreae, the intrahemocytic parasite of the flat oyster Ostrea edulis. | Morvan, A., et al. 1994. Mol Mar Biol Biotechnol. 3: 327-33. PMID: 7704115
- Magainin-induced cytotoxicity in eukaryotic cells: kinetics, dose-response and channel characteristics. | Haimovich, B. and Tanaka, JC. 1995. Biochim Biophys Acta. 1240: 149-58. PMID: 8541286
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Magainin 1, 0.5 mg | sc-391320 | 0.5 mg | $150.00 | |||
Magainin 1, 1 mg | sc-391320A | 1 mg | $330.00 |