Madecassic acid CAS: 18449-41-7
MF: C30H48O6
MW: 504.70

Madecassic acid (CAS 18449-41-7)

Madecassic acid | CAS 18449-41-7 is rated 5.0 out of 5 by 1.
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Alternate Names: Madecassic acid is also known as Brahmic acid.
Application: Madecassic acid is a natural triterpene immunomodulator and inflammatory agent isolated from C. asiatica..
CAS Number: 18449-41-7
Purity: ≥95%
Molecular Weight: 504.70
Molecular Formula: C30H48O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Madecassic acid is one of the three triterpenes isolated from Centella asiatica. The wound healing property of Madecassic acid has been attributed to its ability to stimulate collagen synthesis. Madecassic acid is a natural immunomodulator with a diverse profile of anti-inflammatory and anti-diabetic effects. The action of Madecassic acid works by blocking NF-κB activation in macrophages and altering lipid metabolism in mice. Studies are underway researching the metabolism of Madecassic acid in vivo.


References

1. Won, J.H., Shin, J.S., Park, H.J., et al.Anti-inflammatory effects of madecassic acid via the suppression of NF-κB pathway in LPS-induced RAW 264.7 macrophage cells. Planta Medica 76(3), 251-257 (2010).
2. Hsu, Y.M., Hung, Y.c., Hu, L., et al.Anti-diabetic effects of madecassic acid and rotundic acid. Nutrients 7(12), 10065-10075 (2015).
3. Xia, B., Bai, L., Li, X., et al.Structural analysis of metabolites of asiatic acid and its analogue madecassic acid in zebrafish using LC/IT-MSn. Molecules 20(2), 3001-3019 (2016).
4. Maquart, F.X. et al. 1990. Connect. Tissue Res. 24(2): 107-120. PMID: 2354631
5. Bonte, F. et al. 1994. Planta Med. 60(2): 133-135. PMID: 8202564

Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol.
Storage :
Store at 4° C
Melting Point :
255-260° C
Boiling Point :
641.7° C
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Optical Activity :
α20D +29.31, c = 1.01 in methanol
IC50 :
PTP1B: IC50 = 12.38 µM (human); TC-PTP: IC50>20 µM (human); Rhodopsin: EC5050 = 0.12 mM (bovine); Rhodopsin: IC50 = 0.18 mM (bovine)
pK Values :
pKa: 4.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD00895441

Download SDS (MSDS)

Certificate of Analysis

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Madecassic acid (CAS 18449-41-7)  Product Citations

See how others have used Madecassic acid (CAS 18449-41-7). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 30274214  Preciado, LM.|Pereañez, JA.|Azhagiya Singam, ER.|Comer, J.| et al. 2018. Toxins (Basel). 10:

PMID: # 30324102  Front Chem. 434.

PMID: # 30679477  Sci Rep. 599.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Xia B; et al Xia B; et al. (PubMed ID: 25685908) utilized Madecassic acid to determine that zebrafish possessed strong metabolic capacity for drug discovery research. -SCBT Publication Review
Date published: 2015-03-06
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