Molecular structure of Madecassic acid, CAS Number: 18449-41-7
Madecassic acid (CAS 18449-41-7)
See product citations (4)
Alternate Names:
Madecassic acid is also known as Brahmic acid.
Application:
Madecassic acid is a natural triterpene immunomodulator and inflammatory agent isolated from C. asiatica..
CAS Number:
18449-41-7
Purity:
≥95%
Molecular Weight:
504.70
Molecular Formula:
C30H48O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Madecassic acid is a triterpenoid compound that is extensively researched for its involvement in various natural processes. In plant science research, madecassic acid is studied for its role in the plant defense mechanisms and the regulation of plant growth. It also serves as a critical tool in the elucidation of biosynthetic pathways for triterpenoids in plant cells. In addition, madecassic acid is of interest in the field of ecology, where it is used to investigate plant-herbivore interactions and its potential impact on ecosystem dynamics. Furthermore, its presence in certain plant species is a subject of investigation for understanding the evolutionary advantages conferred by secondary metabolites. The research involving madecassic acid is fundamental to advancing knowledge in plant biology and the application of natural products in various scientific domains.
Madecassic acid (CAS 18449-41-7) References
- [Separation and determination of madecassic acid in triterpenic genins of Centella asiatica by high performance liquid chromatography using beta-cyclodextrin as mobile phase additive]. | Pan, J., et al. 2007. Se Pu. 25: 316-8. PMID: 17679419
- Molecular dynamics simulation and thermodynamic modeling of the self-assembly of the triterpenoids asiatic acid and madecassic acid in aqueous solution. | Stephenson, BC., et al. 2008. J Phys Chem B. 112: 2357-71. PMID: 18247591
- Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells. | Won, JH., et al. 2010. Planta Med. 76: 251-7. PMID: 19774506
- Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica. | Maquart, FX., et al. 1990. Connect Tissue Res. 24: 107-20. PMID: 2354631
- Madecassic acid inhibits the mouse colon cancer growth by inducing apoptosis and immunomodulation. | Zhang, H., et al. 2014. J BUON. 19: 372-6. PMID: 24965394
- Structural analysis of metabolites of asiatic acid and its analogue madecassic acid in zebrafish using LC/IT-MSn. | Xia, B., et al. 2015. Molecules. 20: 3001-19. PMID: 25685908
- Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid. | Hsu, YM., et al. 2015. Nutrients. 7: 10065-75. PMID: 26633490
- Madecassic Acid protects against hypoxia-induced oxidative stress in retinal microvascular endothelial cells via ROS-mediated endoplasmic reticulum stress. | Yang, B., et al. 2016. Biomed Pharmacother. 84: 845-852. PMID: 27728894
- Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway. | Xu, X., et al. 2017. Cell Death Dis. 8: e2723. PMID: 28358365
- Beneficial effects of murtilla extract and madecassic acid on insulin sensitivity and endothelial function in a model of diet-induced obesity. | Arancibia-Radich, J., et al. 2019. Sci Rep. 9: 599. PMID: 30679477
- Inhibition of the activation of γΔT17 cells through PPARγ-PTEN/Akt/GSK3β/NFAT pathway contributes to the anti-colitis effect of madecassic acid. | Yun, X., et al. 2020. Cell Death Dis. 11: 752. PMID: 32929062
- Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer's Disease Model Mice. | Matthews, DG., et al. 2020. Nutrients. 12: PMID: 33202902
- Madecassic acid alleviates colitis-associated colorectal cancer by blocking the recruitment of myeloid-derived suppressor cells via the inhibition of IL-17 expression in γΔT17 cells. | Yun, X., et al. 2022. Biochem Pharmacol. 202: 115138. PMID: 35700756
- Centella asiatica (L.) Urb. Extract ameliorates branched-chain amino acid (BCAA) metabolism in acute reserpine-induced stress zebrafish model via 1H Nuclear Magnetic Resonance (NMR)-based metabolomics approach. | Zakaria, F., et al. 2023. Comp Biochem Physiol C Toxicol Pharmacol. 264: 109501. PMID: 36336330
- Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis. | Bonte, F., et al. 1994. Planta Med. 60: 133-5. PMID: 8202564
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Madecassic acid, 500 mg | sc-391157 | 500 mg | $399.00 | |||
Madecassic acid, 1 g | sc-391157A | 1 g | $649.00 | |||
Madecassic acid, 5 g | sc-391157B | 5 g | $1437.00 |