Molecular structure of Maculosin, CAS Number: 4549-02-4
Maculosin (CAS 4549-02-4)
Alternate Names:
Cyclo-(Pro-Tyr)
Application:
Maculosin is a secondary metabolite of fungi and bacteria
CAS Number:
4549-02-4
Molecular Weight:
260.29
Molecular Formula:
C14H16N2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Maculosin is a diketopiperazine formed by the fusion of tyrosine and proline, reported as a secondary metabolite of fungi and bacteria. In Pseudomonas aeruginosa, maculosin is capable of activating N-acylhomoserine lactones (AHLs). Maculosin is also capable of activating or antagonizing other LuxR-based quorum-sensing systems. While the mode of action of maculosin is not known, its activity suggests the existence of cross talk among bacterial signalling systems. Maculosin was identified as a host-specific toxin produced by Alternaria alternata on spotted knapweed.
Maculosin (CAS 4549-02-4) References
- Synergistic antimicrobial activity of metabolites produced by a nonobligate bacterial predator. | Cain, CC., et al. 2003. Antimicrob Agents Chemother. 47: 2113-7. PMID: 12821455
- Cholesterol modulates maculosin's orientation in model systems of biological membranes. Relevance towards putative molecular recognition. | Lopes, SC., et al. 2004. Steroids. 69: 825-30. PMID: 15582538
- Maculosin, a host-specific phytotoxin for spotted knapweed from Alternaria alternata. | Stierle, AC., et al. 1988. Proc Natl Acad Sci U S A. 85: 8008-11. PMID: 16593989
- Probable novel MEP pathway inhibitor and its binding protein, IspG. | Nakagawa, K., et al. 2013. Biosci Biotechnol Biochem. 77: 1449-54. PMID: 23832336
- Isolation, identification, optimization, and metabolite profiling of Streptomyces sparsus VSM-30. | Managamuri, U., et al. 2017. 3 Biotech. 7: 217. PMID: 28669076
- A rare diketopiperazine glycoside from marine-sourced Streptomyces sp. ZZ446. | Chen, S., et al. 2020. Nat Prod Res. 34: 1046-1050. PMID: 30580590
- Methyl t-butyl ether-degrading bacteria for bioremediation and biocontrol purposes. | d'Errico, G., et al. 2020. PLoS One. 15: e0228936. PMID: 32084150
- Maculosin, a non-toxic antioxidant compound isolated from Streptomyces sp. KTM18. | Paudel, B., et al. 2021. Pharm Biol. 59: 933-936. PMID: 34236286
- Metabolomics Insights into Chemical Convergence in Xanthomonas perforans and Metabolic Changes Following Treatment with the Small Molecule Carvacrol. | Jibrin, MO., et al. 2021. Metabolites. 11: PMID: 34940636
- Metabolic and pharmacological profiling of Penicillium claviforme by a combination of experimental and bioinformatic approaches. | Ali Shah, Z., et al. 2022. Ann Med. 54: 2102-2114. PMID: 35942863
- A New Saharan Strain of Streptomyces sp. GSB-11 Produces Maculosin and N-acetyltyramine Active Against Multidrug-Resistant Pathogenic Bacteria. | Driche, EH., et al. 2022. Curr Microbiol. 79: 298. PMID: 36002540
- Analysis of the Antioxidant Composition of Low Molecular Weight Metabolites from the Agarolytic Bacterium Alteromonas macleodii QZ9-9: Possibilities for High-Added Value Utilization of Macroalgae. | Wang, X., et al. 2022. Antioxidants (Basel). 11: PMID: 36290700
- Antimicrobial Properties of Bacillus Probiotics as Animal Growth Promoters. | Tran, C., et al. 2023. Antibiotics (Basel). 12: PMID: 36830317
- Cellular protein receptors of maculosin, a host specific phytotoxin of spotted knapweed (Centaurea maculosa L.). | Park, SH. and Strobel, GA. 1994. Biochim Biophys Acta. 1199: 13-9. PMID: 8280748
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Maculosin, 250 mg | sc-391788 | 250 mg | $213.00 |