Macrophage Marker Antibody (MAC387): sc-66204

Macrophage Marker Antibody (MAC387) is a mouse monoclonal IgG1 kappa light chain antibody that detects Macrophage Marker protein in mouse, rat, and human samples by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-Macrophage Marker antibody (MAC387) is available in non-conjugated form and conjugated to agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® dyes, offering flexibility for various experimental applications. Macrophage Marker protein (MAC387) plays a key role in immune system function, specifically in pathogen and debris identification and clearance, which maintains tissue homeostasis and triggers immune responses. Macrophages expressing Macrophage Marker protein develop from circulating monocytes and reside in tissues as primary infection defenders. Macrophage Marker protein enables rapid pathogen phagocytosis and degradation without prior sensitization, making this protein essential for innate immunity against various infectious agents. Macrophage Marker protein interactions with specific signaling molecules enhance communication between immune cells, coordinating immune responses and highlighting this protein′s significance in both innate immunity and overall organism health.

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Macrophage Marker Antibody (MAC387) References:

1. Human osteoblast-like cells phagocytose metal particles and express the macrophage marker CD68 in vitro.  |  Heinemann, DE., et al. 2000. J Bone Joint Surg Br. 82: 283-9. PMID: 10755442
2. Salmonella enterica serovar Pullorum persists in splenic macrophages and in the reproductive tract during persistent, disease-free carriage in chickens.  |  Wigley, P., et al. 2001. Infect Immun. 69: 7873-9. PMID: 11705970
3. Expression of the fibroblast/macrophage marker 1B10 by spindle cells in Kaposi's sarcoma lesions and by Kaposi's sarcoma-derived tumor cells.  |  Simonart, T., et al. 2002. J Cutan Pathol. 29: 72-8. PMID: 12150136
4. Monocyte and macrophage heterogeneity.  |  Gordon, S. and Taylor, PR. 2005. Nat Rev Immunol. 5: 953-64. PMID: 16322748
5. The mononuclear phagocyte system.  |  Hume, DA. 2006. Curr Opin Immunol. 18: 49-53. PMID: 16338128
6. Regulation of osteoclast differentiation.  |  Roodman, GD. 2006. Ann N Y Acad Sci. 1068: 100-9. PMID: 16831910
7. Heterogeneity of human peripheral blood eosinophil-type colonies: evidence for a common basophil-eosinophil progenitor.  |  Denburg, JA., et al. 1985. Blood. 66: 312-8. PMID: 2410064
8. Production of phagocytosis-inducing factor and expression of 4B4 antigen by cloned human T cells before and after transformation with HTLV-I.  |  Margolick, JB., et al. 1988. Cell Immunol. 111: 196-203. PMID: 2827893
9. The immunological events leading to the 'in vitro' response to PPD.  |  Scordamaglia, A., et al. 1987. Allergol Immunopathol (Madr). 15: 83-7. PMID: 3113220
10. Immunohistochemical characterisation of macrophages in human liver and gastrointestinal tract: expression of CD4, HLA-DR, OKM1, and the mature macrophage marker 25F9 in normal and diseased tissue.  |  Hume, DA., et al. 1987. J Leukoc Biol. 42: 474-84. PMID: 3500252
11. An immunohistochemical study of IgG, complement C3, collagen type III and macrophage-marker Ki-M7 in epiretinal membranes.  |  Shi, Y., et al. 1996. Yan Ke Xue Bao. 12: 10-4. PMID: 9275730
12. Characterisation of chicken monocytes, macrophages and interdigitating cells by the monoclonal antibody KUL01.  |  Mast, J., et al. 1998. Vet Immunol Immunopathol. 61: 343-57. PMID: 9613446

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Macrophage Marker Antibody (MAC387) has 24 citations in a variety of scientific publications.

Primary antibodies like Anti-Macrophage Marker Antibody (MAC387) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Macrophage Marker Antibody (MAC387) Specifications

Alternate Product Name: Phagocyte Marker

Product Clone Name: MAC387

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Macrophage Marker

Epitope Species: human

Product Reactivity/Detection: macrophages

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 24 citations in various scientific publications

Available Conjugates/Forms for Macrophage Marker Antibody (MAC387): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin