m-Iodobenzylguanidine hemisulfate salt CAS: 80663-95-2
MF: C8H10IN3·1/2H2SO4
MW: 324.13
An inhibitor of arginine specific mono-ADP-ribosyltransferase.

m-Iodobenzylguanidine hemisulfate salt (CAS 80663-95-2)

m-Iodobenzylguanidine hemisulfate salt | CAS 80663-95-2 is rated 5.0 out of 5 by 1.
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Synonym: MIBG
Application: An inhibitor of arginine specific mono-ADP-ribosyltransferase
CAS Number: 80663-95-2
Purity: ≥99%
Molecular Weight: 324.13
Molecular Formula: C8H10IN3·1/2H2SO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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m-Imodobenzylguanidine is a norephinephrine analog anti-tumor agent and radiopharmaceutical in its radioiodinated form. Has shown anti-tumor effects on L1210 leukemia and N1E1115 neuroblastoma. Useful for diagnosing and treating adrenergic/neuroendocrine. Blocks ADP-ribosylation-dependent signal transduction pathways.


References

1. Smets, L.A., et al. 1988. Cancer Chemother. Pharmacol. 21: 9-13. PMID: 3342472
2. Loesberg, C., et al. 1990. Biochim. Biophys. Acta. 1037: 92-99. PMID: 2104758
3. Postema, E.J., et al. 2009. Cancer Biother. Radiopharm. 24: 519-525. PMID: 19877881
4. Kobayashi, S., et al. 2009. Psychiatry Res. 174: 76-80. PMID: 19766460

Physical State :
Solid
Solubility :
Soluble in water (20 mg/ml)
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11957572
Merck Index :
14: 5007
MDL Number :
MFCD00151189
SMILES :
C1(=CC(=CC=C1)I)CN([H])C(N([H])[H])=N[H].[S](O[H])(O[H])(=O)=O

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Certificate of Analysis

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m-Iodobenzylguanidine hemisulfate salt  Product Citations

See how others have used m-Iodobenzylguanidine hemisulfate salt. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 20085326  Gourand, F. et al. 2010. J. Med. Chem. 53: 1281-1287.

PMID: # 2143421  Smets, LA. et al. 1990. Biochim. Biophys. Acta. 1054: 49-55.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from No comment No comment
Date published: 2015-03-25
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