M-ficolin Antibody (036-05-1): sc-80486

M-ficolin Antibody (036-05-1) is a mouse monoclonal IgG1 antibody that detects M-ficolin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-M-ficolin antibody (036-05-1) is available as the non-conjugated format. M-ficolin, also known as ficolin-A, ficolin-1, ficolin-α, FCN1, FCNM, or collagen/fibrinogen domain containing protein 1, is a 326 amino acid member of the ficolin lectin family, characterized by a short N-terminus, one collagen-like domain, and one fibrinogen-like domain at C-terminus. M-ficolin (FCN1) plays a crucial role in innate immune response, primarily functioning as a pattern recognition molecule that identifies and binds to specific carbohydrate structures on pathogens, thereby facilitating their clearance. M-ficolin is predominantly expressed in peripheral blood leukocytes and is secreted into plasma, where M-ficolin interacts with elastin, carbohydrates, and corticosteroids. Notably, M-ficolin exists as a homopolymer through intermolecular disulfide bonding, which is essential for lectin activity, as M-ficolin activates complement pathways via association with mannan-binding lectin serine proteases (MASPs) and specific carbohydrate ligands. M-ficolin′s ability to recognize and bind to various ligands underscores FCN1′s importance in modulating immune responses and maintaining homeostasis in the human body.

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M-ficolin Antibody (036-05-1) References:

1. Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2.  |  Hummelshoj, T., et al. 2005. Hum Mol Genet. 14: 1651-8. PMID: 15879437
2. Human M-ficolin is a secretory protein that activates the lectin complement pathway.  |  Liu, Y., et al. 2005. J Immunol. 175: 3150-6. PMID: 16116205
3. M-ficolin, an innate immune defence molecule, binds patterns of acetyl groups and activates complement.  |  Frederiksen, PD., et al. 2005. Scand J Immunol. 62: 462-73. PMID: 16305643
4. Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins.  |  Thiel, S. 2007. Mol Immunol. 44: 3875-88. PMID: 17768106
5. Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch.  |  Garlatti, V., et al. 2007. J Biol Chem. 282: 35814-20. PMID: 17897951
6. Expression of M-Ficolin in human monocytes and macrophages.  |  Frankenberger, M., et al. 2008. Mol Immunol. 45: 1424-30. PMID: 17928056
7. Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen).  |  Hummelshoj, T., et al. 2008. Mol Immunol. 45: 1623-32. PMID: 18006063
8. Two oligomeric forms of plasma ficolin have differential lectin activity.  |  Ohashi, T. and Erickson, HP. 1997. J Biol Chem. 272: 14220-6. PMID: 9162054

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-M-ficolin Antibody (036-05-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-M-ficolin Antibody (036-05-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

M-ficolin Antibody (036-05-1) Specifications

Alternate Product Name: M-ficolin

Product Clone Name: 036-05-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: M-ficolin

Epitope Species: human

Product Reactivity/Detection: M-ficolin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for M-ficolin Antibody (036-05-1): N/A