Molecular structure of m-3M3FBS, CAS Number: 200933-14-8
m-3M3FBS (CAS 200933-14-8)
See product citations (10)
Alternate Names:
2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Application:
m-3M3FBS is a cell-permeable PLC activator that up-regulates Bax levels and down-regulates Bcl-2 levels
CAS Number:
200933-14-8
Purity:
≥97%
Molecular Weight:
343.36
Molecular Formula:
C16H16F3NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
m-3M3FBS is the active compound 2,4,6-trimethyl-N-(meta-3-trifluoromethyl-phenyl)-benzenesulfonamide. This agent may act to stimulate calcium concentration increase in neutrophils by directly activating phosphoinositide-specific phospholipase C (PLC). Experiments suggest that m-3M3FBS is capable of inhibiting growth of certain cell lines and causes chromatin condensation as well as DNA fragmentation. Furthermore, m-3M3FBS-induced apoptosis was correlated to up-regulation of pro-apoptotic Bax, down-regulation of anti-apoptotic Bcl-2, caspase activation, and release of Cytochrome c.
m-3M3FBS (CAS 200933-14-8) References
- Identification of a compound that directly stimulates phospholipase C activity. | Bae, YS., et al. 2003. Mol Pharmacol. 63: 1043-50. PMID: 12695532
- Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. | Krjukova, J., et al. 2004. Br J Pharmacol. 143: 3-7. PMID: 15302681
- The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. | Lee, YN., et al. 2005. Cancer Lett. 222: 227-35. PMID: 15863272
- Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. | Dai, Y., et al. 2007. J Clin Invest. 117: 1979-87. PMID: 17571167
- The novel phospholipase C activator, m-3M3FBS, induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling. | Jung, EM., et al. 2008. Apoptosis. 13: 133-45. PMID: 18060503
- Effect of m-3M3FBS on Ca(2+) movement in Madin-Darby canine renal tubular cells. | Fang, YC., et al. 2009. Hum Exp Toxicol. 28: 655-63. PMID: 19770166
- Effect of m-3m3FBS on Ca2+ handling and viability in OC2 human oral cancer cells. | Chi, CC., et al. 2012. Acta Physiol Hung. 99: 74-86. PMID: 22425810
- Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis. | Kim, SD., et al. 2012. J Immunol. 189: 2000-5. PMID: 22798676
- M-3M3FBS-induced Ca² ⁺ movement and apoptosis in HA59T human hepatoma cells. | Liu, SI., et al. 2013. Chin J Physiol. 56: 26-35. PMID: 23347013
- Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons. | Szebenyi, SA., et al. 2014. Front Cell Neurosci. 8: 336. PMID: 25374507
- 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide increases calcium influx in lipopolisaccharide-pre-treated arteries. | Grześk, E., et al. 2017. Exp Ther Med. 13: 766-770. PMID: 28352364
- The effects of phospholipase C on oestradiol and progesterone secretion in porcine granulosa cells cultured in vitro. | Chen, H., et al. 2019. Reprod Domest Anim. 54: 1236-1243. PMID: 31319005
- Phospholipase C inhibits apoptosis of porcine primary granulosa cells cultured in vitro. | Chen, H., et al. 2019. J Ovarian Res. 12: 90. PMID: 31554511
- Phospholipase C inhibits apoptosis of porcine oocytes cultured in vitro. | Chen, HL., et al. 2020. J Cell Biochem. 121: 3547-3559. PMID: 31898356
- Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak. | Quarato, G., et al. 2022. Cell Death Differ. 29: 1318-1334. PMID: 35726022
Inhibitor of:
PLC β2.Activator of:
Endophilin II, NHEDC1, Otolin-1, PLC, PLC β4, PLC δ3, and PLC η2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
m-3M3FBS, 10 mg | sc-202217 | 10 mg | $141.00 | |||
m-3M3FBS, 50 mg | sc-202217A | 50 mg | $630.00 |