LZIP Antibody (Q-61): sc-100994

LZIP Antibody (Q-61) is a mouse monoclonal IgG2a antibody that detects LZIP in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). LZIP, a member of the ATF/CREB family, is a type II membrane-associated glycoprotein that plays a crucial role in cellular processes by activating transcription from genes containing cyclic AMP response elements (CREs). This function is particularly important as LZIP regulates gene expression in response to cellular signaling pathways, thereby influencing cell proliferation and differentiation. LZIP is predominantly located in the endoplasmic reticulum, where LZIP interacts with HCF-1, a cellular protein essential for the activation of herpes simplex virus immediate-early genes. The interaction between LZIP and HCF-1 is mediated by a specific binding motif, which underscores the importance of their relationship in transcriptional regulation. Additionally, LZIP′s activity can be inhibited by HCLP-1, highlighting the intricate balance of coactivators and repressors that govern gene expression. With versatile applications and critical role in cellular signaling, anti-LZIP antibody (Q-61) serves as an invaluable tool for researchers studying gene regulation and viral interactions.

The preferred LZIP antibody is LZIP Antibody (H-7): sc-515434.